HitPredict

Interactor 1: SOCS1 (O35716)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1)
Gene: SOCS1

Interactor 2: TRIM8 (Q99PJ2)
E3 ubiquitin-protein ligase TRIM8 (EC 2.3.2.27) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (RING-type E3 ubiquitin transferase TRIM8) (Tripartite motif-containing protein 8)
Gene: TRIM8

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	12163497
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 212 Mm			1 551
+	Hs
		181891 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		TRIM8_HUMAN (1-551): 3.06e-126: 382: 97.64
+	Hs
		557799 NCK1_HUMAN (4-175): 1.37e-40: 143: 18.39		TRI39_HUMAN (6-496): 5.61e-82: 267: 15.15
+	Hs
		208986 NCK2_HUMAN (2-176): 2.33e-43: 151: 18.64		TRI27_HUMAN (1-512): 1.78e-76: 252: 12.57
+	Hs
		412363 FYN_HUMAN (69-195): 3.04e-36: 134: 18.98		TRI39_HUMAN (6-496): 5.61e-82: 267: 15.15
+	Hs
		411977 FYN_HUMAN (69-195): 3.04e-36: 134: 18.98		TRI27_HUMAN (1-512): 1.78e-76: 252: 12.57
+	Hs
		181892 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		TRIM5_HUMAN (1-521): 5.85e-69: 231: 12.66
+	Hs
		1172216 VAV3_HUMAN (12-210): 1.04e-37: 140: 16.08		TRI67_HUMAN (50-548): 2.65e-64: 226: 15.59
+	Hs
		433465 YES_HUMAN (69-197): 1.59e-35: 132: 16.55		TRIM5_HUMAN (1-521): 5.85e-69: 231: 12.66
+	Hs
		789076 ABL2_HUMAN (71-193): 1.95e-36: 136: 19.05		TRI67_HUMAN (50-548): 2.65e-64: 226: 15.59
+	Hs
		855804 VAV2_HUMAN (3-176): 8.33e-36: 134: 15.52		TRI67_HUMAN (50-548): 2.65e-64: 226: 15.59
+	Hs
		561394 FER_HUMAN (4-177): 2.53e-35: 133: 16.02		TRI67_HUMAN (50-548): 2.65e-64: 226: 15.59
+	Hs
		433394 YES_HUMAN (69-197): 1.59e-35: 132: 16.55		TRI67_HUMAN (50-548): 2.65e-64: 226: 15.59
+	Hs
		412344 FYN_HUMAN (69-195): 3.04e-36: 134: 18.98		TRI55_HUMAN (2-347): 3.92e-52: 188: 18.85
+	Hs
		412294 FYN_HUMAN (69-195): 3.04e-36: 134: 18.98		TRI63_HUMAN (2-352): 2.12e-53: 186: 19.73
+	Hs
		129310 P85B_HUMAN (76-175): 4.12e-18: 84.1: 27.00		TRI67_HUMAN (50-548): 2.65e-64: 226: 15.59
+	Hs
		1267430 P55G_HUMAN (38-172): 5.2e-23: 97.5: 13.99		TRI54_HUMAN (2-347): 9.25e-60: 204: 18.58
+	Hs
		1232033 Q8N381_HUMAN (38-172): 1.56e-22: 96.3: 13.99		TRI54_HUMAN (2-347): 9.25e-60: 204: 18.58
+	Hs
		655365 P85A_HUMAN (76-181): 2.01e-17: 81.7: 23.59		TRI25_HUMAN (6-378): 7.44e-58: 205: 21.85