HitPredict

Interactor 1: SOCS1 (O35716)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1)
Gene: SOCS1

Interactor 2: FAK2 (Q9QVP9)
Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
Gene: Ptk2b

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.555

Property	Details
Experiments	10679268
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 212 Mm			1 1009
+	Hs
		181850 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		FAK1_HUMAN (39-1000): 0: 803: 44.05
+	Hs
		209036 NCK2_HUMAN (2-176): 2.33e-43: 151: 18.64		FAK1_HUMAN (39-1000): 0: 803: 44.05
+	Mm
		193375 SOCS3_MOUSE (38-208): 4.45e-43: 146: 27.35		FAK1_MOUSE (39-1000): 0: 799: 44.05
+	Hs
		146668 SOCS7_HUMAN (30-210): 1.96e-47: 165: 22.55		YES_HUMAN (272-694): 3.51e-127: 398: 27.23
+	Hs
		181783 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		SRC_HUMAN (256-694): 2.06e-129: 404: 26.92
+	Hs
		181765 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		FYN_HUMAN (247-694): 2.21e-127: 399: 26.13
+	Hs
		181770 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		YES_HUMAN (272-694): 3.51e-127: 398: 27.23
+	Hs
		181764 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		LCK_HUMAN (272-694): 8.62e-127: 396: 28.97
+	Hs
		181758 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		ERBB2_HUMAN (309-908): 4.43e-117: 391: 24.67
+	Hs
		208972 NCK2_HUMAN (2-176): 2.33e-43: 151: 18.64		ERBB2_HUMAN (309-908): 4.43e-117: 391: 24.67
+	Hs
		181866 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		ERBB4_HUMAN (413-885): 3.86e-116: 389: 28.96
+	Hs
		209056 NCK2_HUMAN (2-176): 2.33e-43: 151: 18.64		ERBB4_HUMAN (413-885): 3.86e-116: 389: 28.96
+	Hs
		256843 SOCS5_HUMAN (8-211): 1.48e-41: 149: 19.81		ERBB2_HUMAN (309-908): 4.43e-117: 391: 24.67
+	Hs
		256853 SOCS5_HUMAN (8-211): 1.48e-41: 149: 19.81		ERBB4_HUMAN (413-885): 3.86e-116: 389: 28.96
+	Hs
		181753 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		ABL1_HUMAN (399-856): 1.17e-115: 384: 28.30
+	Hs
		181771 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		LYN_HUMAN (197-694): 2.83e-120: 379: 25.88
+	Hs
		208983 NCK2_HUMAN (2-176): 2.33e-43: 151: 18.64		FGFR1_HUMAN (298-743): 2.36e-115: 376: 26.17
+	Hs
		181816 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		TEC_HUMAN (301-687): 4.84e-115: 369: 26.80
+	Hs
		181796 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		FGFR3_HUMAN (351-685): 8.35e-109: 358: 30.66
+	Hs
		209018 NCK2_HUMAN (2-176): 2.33e-43: 151: 18.64		EPHA4_HUMAN (425-682): 2.57e-55: 210: 40.61