HitPredict

Interactor 1: SOCS2 (O35717)
Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2)
Gene: SOCS2

Interactor 2: LEPR (P48356)
Leptin receptor (LEP-R) (B219) (OB receptor) (OB-R) (CD antigen CD295)
Gene: LEPR

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.50	0.526

Property	Details
Experiments	16684815, 16698021
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 198 Mm			1 1162
+	Mm
		817307 SOCS7_MOUSE (31-196): 1.48e-50: 173: 31.03		LEPR_MOUSE (1-1162): 0: 1013: 100.00
+	Mm
		193379 SOCS3_MOUSE (28-194): 6.91e-49: 160: 29.59		LEPR_MOUSE (1-1162): 0: 1013: 100.00
+	Mm
		817306 CISH_MOUSE (12-198): 9e-42: 142: 36.92		LEPR_MOUSE (1-1162): 0: 1013: 100.00
+	Mm
		817309 SOCS6_MOUSE (26-196): 3.22e-38: 139: 30.90		LEPR_MOUSE (1-1162): 0: 1013: 100.00
+	Hs
		147403 SOCS3_HUMAN (28-194): 1.96e-49: 161: 29.59		LEPR_HUMAN (1-1162): 0: 962: 75.39
+	Hs
		412016 FYN_HUMAN (1-172): 4.72e-44: 155: 14.92		PTPRD_HUMAN (41-931): 6.81e-92: 327: 13.98
+	Hs
		411959 FYN_HUMAN (1-172): 4.72e-44: 155: 14.92		PTPRF_HUMAN (24-869): 2e-83: 301: 12.06
+	Mm
		56907 FYN_MOUSE (1-172): 4.21e-44: 155: 14.92		PTPRF_MOUSE (24-866): 4.53e-83: 300: 11.85
+	Hs
		411565 LCK_HUMAN (2-171): 2.64e-38: 139: 16.76		PTPRF_HUMAN (24-869): 2e-83: 301: 12.06
+	Dm
		337644 ABL_DROME (1-173): 3.36e-40: 147: 18.18		LAR_DROME (224-861): 3.81e-52: 203: 15.08
+	Hs
		146590 SOCS2_HUMAN (1-198): 5.58e-65: 200: 93.94		PRLR_HUMAN (425-624): 5.8e-15: 81.7: 22.86
+	Mm
		193384 SOCS3_MOUSE (28-194): 6.91e-49: 160: 29.59		IL6RB_MOUSE (268-883): 1.16e-17: 91.1: 13.57
+	Hs
		147398 SOCS3_HUMAN (28-194): 1.96e-49: 161: 29.59		IL6RB_HUMAN (426-883): 3.44e-16: 86: 14.75
+	Hs
		147385 SOCS3_HUMAN (28-194): 1.96e-49: 161: 29.59		PRLR_HUMAN (425-624): 5.8e-15: 81.7: 22.86
+	Hs
		442787 HCK_HUMAN (1-171): 1.16e-40: 146: 13.33		IL6RB_HUMAN (426-883): 3.44e-16: 86: 14.75
+	Hs
		147443 SOCS3_HUMAN (28-194): 1.96e-49: 161: 29.59		I12R2_HUMAN (501-819): 9.46e-11: 68.3: 13.86
+	Hs
		147442 SOCS3_HUMAN (28-194): 1.96e-49: 161: 29.59		CSF3R_HUMAN (249-880): 1.03e-09: 64.9: 11.93
+	Mm
		435879 HCK_MOUSE (1-174): 1.02e-40: 146: 13.66		CSF3R_MOUSE (186-662): 5.09e-11: 69.1: 13.55
+	Hs
		442875 HCK_HUMAN (1-171): 1.16e-40: 146: 13.33		CSF3R_HUMAN (249-880): 1.03e-09: 64.9: 11.93
+	Mm
		411919 LCK_MOUSE (2-171): 3.59e-38: 139: 16.76		CSF3R_MOUSE (186-662): 5.09e-11: 69.1: 13.55