HitPredict

Interactor 1: SOCS2 (O35717)
Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2)
Gene: SOCS2

Interactor 2: FLT3 (Q00342)
Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase 2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Tyrosine-protein kinase receptor flk-2) (CD antigen CD135)
Gene: FLT3

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	23548639
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 198 Mm			1 1000
+	Hs
		146603 SOCS2_HUMAN (1-198): 5.58e-65: 200: 93.94		FLT3_HUMAN (1-995): 0: 780: 84.18
+	Hs
		412062 FYN_HUMAN (1-172): 4.72e-44: 155: 14.92		FLT3_HUMAN (1-995): 0: 780: 84.18
+	Hs
		146585 SOCS2_HUMAN (1-198): 5.58e-65: 200: 93.94		KIT_HUMAN (33-990): 0: 610: 29.28
+	Hs
		147381 SOCS3_HUMAN (28-194): 1.96e-49: 161: 29.59		KIT_HUMAN (33-990): 0: 610: 29.28
+	Hs
		411962 FYN_HUMAN (1-172): 4.72e-44: 155: 14.92		KIT_HUMAN (33-990): 0: 610: 29.28
+	Hs
		433226 YES_HUMAN (1-175): 2.33e-43: 153: 14.13		KIT_HUMAN (33-990): 0: 610: 29.28
+	Dm
		112231 SRC42_DROME (1-173): 1.07e-44: 156: 18.64		M9MRE1_DROME (125-965): 1.58e-131: 434: 21.33
+	Hs
		433229 YES_HUMAN (1-175): 2.33e-43: 153: 14.13		FGFR1_HUMAN (28-274): 3.74e-46: 180: 9.97
+	Hs
		412008 FYN_HUMAN (1-172): 4.72e-44: 155: 14.92		FGFR2_HUMAN (52-367): 3.31e-26: 117: 15.03
+	Hs
		411995 FYN_HUMAN (1-172): 4.72e-44: 155: 14.92		VGFR1_HUMAN (19-786): 1.25e-25: 116: 9.19
+	Hs
		433247 YES_HUMAN (1-175): 2.33e-43: 153: 14.13		VGFR1_HUMAN (19-786): 1.25e-25: 116: 9.19
+	Hs
		147375 SOCS3_HUMAN (28-194): 1.96e-49: 161: 29.59		CSF1R_HUMAN (18-455): 6.65e-22: 104: 9.71
+	Hs
		411943 FYN_HUMAN (1-172): 4.72e-44: 155: 14.92		CSF1R_HUMAN (18-455): 6.65e-22: 104: 9.71
+	Mm
		452181 FYN_MOUSE (1-172): 4.21e-44: 155: 14.92		CSF1R_MOUSE (18-453): 1.21e-21: 103: 10.25
+	Hs
		426975 YES_HUMAN (1-175): 2.33e-43: 153: 14.13		CSF1R_HUMAN (18-455): 6.65e-22: 104: 9.71
+	Hs
		411953 FYN_HUMAN (1-172): 4.72e-44: 155: 14.92		PGFRB_HUMAN (18-413): 3.26e-15: 82.9: 11.56
+	Hs
		433221 YES_HUMAN (1-175): 2.33e-43: 153: 14.13		PGFRB_HUMAN (18-413): 3.26e-15: 82.9: 11.56
+	Mm
		404012 FYN_MOUSE (1-172): 4.21e-44: 155: 14.92		PGFRB_MOUSE (18-459): 1.47e-14: 80.6: 10.55
+	Hs
		147391 SOCS3_HUMAN (28-194): 1.96e-49: 161: 29.59		FGFR3_HUMAN (163-444): 1.45e-09: 64: 11.08
+	Hs
		412060 FYN_HUMAN (1-172): 4.72e-44: 155: 14.92		VGFR2_HUMAN (20-151): 1.68e-10: 67.5: 14.39