HitPredict

Interactor 1: SOCS2 (O35717)
Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2)
Gene: SOCS2

Interactor 2: CISH (Q62225)
Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS)
Gene: CISH

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.786

Property	Details
Experiments	16684815, 16956890
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, transcriptional complementation assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SOCS_box
Common GO terms	GO:0005942 - phosphatidylinositol 3-kinase complex GO:0016567 - protein ubiquitination GO:0035556 - intracellular signal transduction GO:0046854 - phosphatidylinositol phosphate biosynthetic process GO:0046935 - 1-phosphatidylinositol-3-kinase regulator activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 198 Mm			1 257
+	Rn
		70069 SOCS2_RAT (1-198): 6.5e-66: 202: 97.98		B1WBX9_RAT (1-257): 1.12e-73: 226: 96.11
+	Hs
		146582 SOCS2_HUMAN (1-198): 5.58e-65: 200: 93.94		YES_HUMAN (31-252): 2.04e-50: 174: 13.52
+	Mm
		193359 SOCS2_MOUSE (1-198): 1.44e-65: 201: 100.00		SOCS2_MOUSE (41-257): 1.74e-50: 165: 37.33
+	Rn
		291945 SOCS2_RAT (1-198): 6.5e-66: 202: 97.98		SOCS2_RAT (41-257): 2.91e-49: 162: 37.79
+	Rn
		291946 SOCS2_RAT (1-198): 6.5e-66: 202: 97.98		SOCS3_RAT (51-253): 1.58e-47: 159: 29.67
+	Hs
		146580 SOCS2_HUMAN (1-198): 5.58e-65: 200: 93.94		LCK_HUMAN (2-251): 3.47e-45: 160: 12.17
+	Hs
		146565 SOCS2_HUMAN (1-198): 5.58e-65: 200: 93.94		SOCS3_HUMAN (51-253): 6.82e-46: 154: 30.14
+	Hs
		146570 SOCS2_HUMAN (1-198): 5.58e-65: 200: 93.94		SOCS1_HUMAN (59-257): 6.41e-44: 149: 28.36
+	Rn
		102467 SOCS2_RAT (1-198): 6.5e-66: 202: 97.98		G3V6B4_RAT (59-257): 5.27e-43: 146: 28.36
+	Hs
		146668 SOCS7_HUMAN (31-196): 1.21e-50: 173: 31.03		YES_HUMAN (31-252): 2.04e-50: 174: 13.52
+	Mm
		193335 SOCS2_MOUSE (1-198): 1.44e-65: 201: 100.00		SOCS1_MOUSE (59-257): 9.33e-43: 146: 28.36
+	Hs
		147377 SOCS3_HUMAN (28-194): 1.96e-49: 161: 29.59		YES_HUMAN (31-252): 2.04e-50: 174: 13.52
+	Dm
		1360389 SRC42_DROME (1-173): 1.07e-44: 156: 18.64		SRC42_DROME (6-213): 1.56e-50: 174: 17.39
+	Hs
		147374 SOCS3_HUMAN (28-194): 1.96e-49: 161: 29.59		LCK_HUMAN (2-251): 3.47e-45: 160: 12.17
+	Dm
		1177327 Q8INY1_DROME (36-197): 1.39e-45: 161: 29.27		Q7JVF1_DROME (26-256): 2.33e-46: 159: 25.00
+	Hs
		147406 SOCS3_HUMAN (28-194): 1.96e-49: 161: 29.59		BLK_HUMAN (8-251): 4.2e-44: 157: 14.95
+	Hs
		146674 SOCS7_HUMAN (31-196): 1.21e-50: 173: 31.03		GRB2_HUMAN (34-217): 2.53e-41: 143: 15.84
+	Hs
		147369 SOCS3_HUMAN (28-194): 1.96e-49: 161: 29.59		ABL1_HUMAN (35-255): 4.21e-41: 152: 11.72