HitPredict

Interactor 1: SOCS2 (O35717)
Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2)
Gene: SOCS2

Interactor 2: CUL5 (Q9D5V5)
Cullin-5 (CUL-5)
Gene: CUL5

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	19385048, 16684815
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 198 Mm			1 780
+	Hs
		146642 SOCS2_HUMAN (1-198): 5.58e-65: 200: 93.94		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		1257617 SOCS7_MOUSE (31-196): 1.48e-50: 173: 31.03		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		146692 SOCS7_HUMAN (31-196): 1.21e-50: 173: 31.03		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		193394 SOCS3_MOUSE (28-194): 6.91e-49: 160: 29.59		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		147440 SOCS3_HUMAN (28-194): 1.96e-49: 161: 29.59		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Hs
		146625 SOCS2_HUMAN (1-198): 5.58e-65: 200: 93.94		CUL4A_HUMAN (16-780): 0: 733: 24.61
+	Hs
		1263831 SOCS4_HUMAN (14-197): 9.97e-43: 150: 26.15		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		1265273 SOCS4_MOUSE (14-197): 7.6e-42: 147: 26.67		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Mm
		222648 SOCS5_MOUSE (36-197): 3.18e-40: 144: 32.32		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		256856 SOCS5_HUMAN (36-197): 1.83e-40: 145: 32.32		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		1143676 CISH_MOUSE (12-198): 9e-42: 142: 36.92		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Mm
		193357 SOCS1_MOUSE (30-198): 3.14e-42: 142: 30.23		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		181885 SOCS1_HUMAN (30-198): 2.83e-42: 142: 30.81		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		1322060 SOCS6_MOUSE (26-196): 3.22e-38: 139: 30.90		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		147544 SOCS6_HUMAN (26-196): 8.79e-39: 141: 30.90		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Hs
		147421 SOCS3_HUMAN (28-194): 1.96e-49: 161: 29.59		CUL4B_HUMAN (16-780): 0: 726: 25.52
+	Hs
		789064 ABL2_HUMAN (1-173): 6.77e-40: 146: 16.48		CUL4A_HUMAN (16-780): 0: 733: 24.61
+	Hs
		337467 ABL1_HUMAN (1-173): 6.29e-38: 140: 17.71		CUL4A_HUMAN (16-780): 0: 733: 24.61
+	Hs
		337468 ABL1_HUMAN (1-173): 6.29e-38: 140: 17.71		CUL4B_HUMAN (16-780): 0: 726: 25.52
+	Hs
		181856 SOCS1_HUMAN (30-198): 2.83e-42: 142: 30.81		CUL2_HUMAN (10-780): 0: 688: 26.37