HitPredict

Interactor 1: SOCS3 (O35718)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10)
Gene: SOCS3

Interactor 2: EPOR (P14753)
Erythropoietin receptor (EPO-R)
Gene: EPOR

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	10882725
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Mm			1 507
+	Hs
		147386 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		EPOR_HUMAN (1-507): 2.65e-139: 412: 81.69
+	Hs
		146592 SOCS2_HUMAN (3-221): 5.64e-48: 158: 28.31		EPOR_HUMAN (1-507): 2.65e-139: 412: 81.69
+	Mm
		540271 CISH_MOUSE (14-225): 1.01e-44: 151: 29.95		EPOR_MOUSE (1-507): 2.85e-136: 405: 100.00
+	Hs
		147382 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		GHR_HUMAN (18-505): 2.17e-84: 275: 15.40
+	Hs
		146586 SOCS2_HUMAN (3-221): 5.64e-48: 158: 28.31		GHR_HUMAN (18-505): 2.17e-84: 275: 15.40
+	Hs
		147385 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		PRLR_HUMAN (42-460): 1.03e-70: 238: 19.03
+	Hs
		146590 SOCS2_HUMAN (3-221): 5.64e-48: 158: 28.31		PRLR_HUMAN (42-460): 1.03e-70: 238: 19.03
+	Hs
		146591 SOCS2_HUMAN (3-221): 5.64e-48: 158: 28.31		IL7RA_HUMAN (121-476): 1.34e-63: 215: 16.44
+	Hs
		147383 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		IL2RB_HUMAN (17-459): 7.87e-54: 192: 16.70
+	Hs
		147442 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		CSF3R_HUMAN (40-447): 3.81e-44: 168: 11.79
+	Hs
		147403 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		LEPR_HUMAN (49-286): 1.17e-30: 128: 17.97
+	Mm
		193379 SOCS3_MOUSE (1-225): 1.74e-58: 185: 100.00		LEPR_MOUSE (49-286): 1.04e-25: 113: 16.47
+	Mm
		193384 SOCS3_MOUSE (1-225): 1.74e-58: 185: 100.00		IL6RB_MOUSE (21-481): 9.92e-22: 101: 14.83
+	Hs
		147443 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		I12R2_HUMAN (7-474): 1.22e-21: 100: 14.29
+	Mm
		193361 SOCS2_MOUSE (3-221): 1.44e-48: 159: 28.31		LEPR_MOUSE (49-286): 1.04e-25: 113: 16.47
+	Mm
		817309 SOCS6_MOUSE (8-220): 4.11e-43: 153: 23.39		LEPR_MOUSE (49-286): 1.04e-25: 113: 16.47
+	Mm
		817306 CISH_MOUSE (14-225): 1.01e-44: 151: 29.95		LEPR_MOUSE (49-286): 1.04e-25: 113: 16.47
+	Hs
		147398 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		IL6RB_HUMAN (17-481): 3.19e-15: 80.8: 14.92
+	Mm
		645937 CISH_MOUSE (14-225): 1.01e-44: 151: 29.95		IL3RB_MOUSE (50-268): 1.46e-11: 69.2: 15.65
+	Mm
		645935 CISH_MOUSE (14-225): 1.01e-44: 151: 29.95		IL3B2_MOUSE (50-268): 6.52e-11: 66.9: 15.32