HitPredict

Interactor 1: SOCS3 (O35718)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10)
Gene: SOCS3

Interactor 2: INSR (P15208)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	15169905
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Mm			1 1372
+	Hs
		147373 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		INSR_HUMAN (28-1372): 0: 1541: 95.06
+	Hs
		147471 SOCS6_HUMAN (8-220): 4.49e-44: 156: 23.39		INSR_HUMAN (28-1372): 0: 1541: 95.06
+	Hs
		147378 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		IGF1R_HUMAN (17-1370): 0: 1321: 56.29
+	Hs
		146583 SOCS2_HUMAN (3-221): 5.64e-48: 158: 28.31		IGF1R_HUMAN (17-1370): 0: 1321: 56.29
+	Hs
		147371 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		ERBB2_HUMAN (10-592): 6.81e-173: 551: 21.99
+	Hs
		147470 SOCS6_HUMAN (8-220): 4.49e-44: 156: 23.39		ERBB2_HUMAN (10-592): 6.81e-173: 551: 21.99
+	Hs
		384022 VAV3_HUMAN (17-207): 9.71e-41: 149: 14.14		ERBB2_HUMAN (10-592): 6.81e-173: 551: 21.99
+	Hs
		146597 SOCS2_HUMAN (3-221): 5.64e-48: 158: 28.31		EPHA2_HUMAN (663-1310): 2.33e-165: 523: 23.41
+	Hs
		147489 SOCS6_HUMAN (8-220): 4.49e-44: 156: 23.39		EPHA2_HUMAN (663-1310): 2.33e-165: 523: 23.41
+	Hs
		146632 SOCS2_HUMAN (3-221): 5.64e-48: 158: 28.31		NTRK2_HUMAN (986-1282): 8.83e-68: 248: 42.72
+	Hs
		147391 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		FGFR3_HUMAN (1005-1277): 7.37e-61: 226: 40.43
+	Dm
		526800 Q8INY1_DROME (21-221): 5.4e-46: 163: 22.66		7LESS_DROME (1012-1280): 1.26e-63: 241: 46.04
+	Hs
		146579 SOCS2_HUMAN (3-221): 5.64e-48: 158: 28.31		NTRK1_HUMAN (986-1276): 9.33e-66: 241: 41.95
+	Hs
		147484 SOCS6_HUMAN (8-220): 4.49e-44: 156: 23.39		FGFR3_HUMAN (1005-1277): 7.37e-61: 226: 40.43
+	Hs
		147390 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		ERBB3_HUMAN (26-369): 1.33e-29: 130: 19.74
+	Hs
		147427 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		ERBB4_HUMAN (31-348): 8.64e-24: 111: 18.23
+	Hs
		146593 SOCS2_HUMAN (3-221): 5.64e-48: 158: 28.31		ERBB3_HUMAN (26-369): 1.33e-29: 130: 19.74
+	Hs
		147483 SOCS6_HUMAN (8-220): 4.49e-44: 156: 23.39		ERBB3_HUMAN (26-369): 1.33e-29: 130: 19.74
+	Hs
		146629 SOCS2_HUMAN (3-221): 5.64e-48: 158: 28.31		ERBB4_HUMAN (31-348): 8.64e-24: 111: 18.23
+	Hs
		147522 SOCS6_HUMAN (8-220): 4.49e-44: 156: 23.39		ERBB4_HUMAN (31-348): 8.64e-24: 111: 18.23