HitPredict

Interactor 1: SOCS3 (O35718)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10)
Gene: SOCS3

Interactor 2: STAT6 (P52633)
Signal transducer and transcription activator 6
Gene: STAT6

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20620946
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH2
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0007259 - cell surface receptor signaling pathway via JAK-STAT
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Mm			1 837
+	Hs
		146609 SOCS2_HUMAN (3-221): 5.64e-48: 158: 28.31		STA5B_HUMAN (1-710): 0: 779: 37.11
+	Mm
		786656 CISH_MOUSE (14-225): 1.01e-44: 151: 29.95		STA5A_MOUSE (1-724): 0: 785: 37.07
+	Hs
		849911 CISH_HUMAN (13-225): 1.2e-43: 148: 28.37		STA5B_HUMAN (1-710): 0: 779: 37.11
+	Hs
		786637 CISH_HUMAN (13-225): 1.2e-43: 148: 28.37		STA5A_HUMAN (1-724): 0: 774: 36.77
+	Hs
		146672 SOCS7_HUMAN (16-221): 2.78e-38: 141: 25.24		STA5A_HUMAN (1-724): 0: 774: 36.77
+	Hs
		849903 P55G_HUMAN (14-153): 2.59e-22: 96: 19.01		STA5B_HUMAN (1-710): 0: 779: 37.11
+	Mm
		193377 SOCS3_MOUSE (1-225): 1.74e-58: 185: 100.00		STAT3_MOUSE (1-684): 0: 689: 25.45
+	Hs
		256851 SOCS5_HUMAN (23-221): 1.3e-39: 144: 21.00		STAT1_HUMAN (1-687): 0: 728: 27.04
+	Hs
		147400 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		STAT3_HUMAN (1-684): 0: 688: 25.45
+	Hs
		522836 SRC_HUMAN (34-179): 1.12e-35: 133: 19.61		STAT1_HUMAN (1-687): 0: 728: 27.04
+	Hs
		146671 SOCS7_HUMAN (16-221): 2.78e-38: 141: 25.24		STAT3_HUMAN (1-684): 0: 688: 25.45
+	Mm
		403422 SRC_MOUSE (34-179): 1.48e-35: 133: 19.61		STAT3_MOUSE (1-684): 0: 689: 25.45
+	Hs
		412065 FYN_HUMAN (34-177): 1.34e-35: 133: 20.53		STAT3_HUMAN (1-684): 0: 688: 25.45
+	Hs
		454804 FGR_HUMAN (34-178): 9.43e-36: 133: 19.08		STAT3_HUMAN (1-684): 0: 688: 25.45
+	Hs
		522829 SRC_HUMAN (34-179): 1.12e-35: 133: 19.61		STAT3_HUMAN (1-684): 0: 688: 25.45
+	Hs
		776638 GRB2_HUMAN (34-174): 7.66e-35: 124: 14.79		STAT3_HUMAN (1-684): 0: 688: 25.45
+	Dm
		1096415 Q8INY1_DROME (21-221): 5.4e-46: 163: 22.66		STAT_DROME (1-675): 0: 641: 29.52
+	Hs
		655247 P85A_HUMAN (14-153): 2.72e-22: 96.4: 16.43		STAT3_HUMAN (1-684): 0: 688: 25.45
+	Dm
		1096410 Q7JVF1_DROME (26-219): 1.56e-40: 143: 19.29		STAT_DROME (1-675): 0: 641: 29.52
+	Hs
		776765 P55G_HUMAN (14-153): 2.59e-22: 96: 19.01		STAT3_HUMAN (1-684): 0: 688: 25.45