HitPredict

Interactor 1: SOCS3 (O35718)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10)
Gene: SOCS3

Interactor 2: IL6RB (Q00560)
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Gene: Il6st

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.853

Property	Details
Experiments	23454976, 16905102, 10829066
Identification Methods	unspecified method, isothermal titration calorimetry, x-ray crystallography, affinity chromatography technology, surface plasmon resonance
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Mm			1 917
+	Hs
		147398 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		IL6RB_HUMAN (1-917): 0: 587: 76.82
+	Hs
		548653 VAV_HUMAN (4-207): 1.17e-35: 134: 12.75		IL6RB_HUMAN (1-917): 0: 587: 76.82
+	Hs
		147443 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		I12R2_HUMAN (9-810): 1.75e-109: 359: 21.37
+	Hs
		147442 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		CSF3R_HUMAN (5-794): 1.53e-99: 332: 24.82
+	Hs
		1303311 CISH_HUMAN (13-225): 1.2e-43: 148: 28.37		CSF3R_HUMAN (5-794): 1.53e-99: 332: 24.82
+	Mm
		56907 FYN_MOUSE (34-177): 1.28e-35: 133: 20.53		PTPRF_MOUSE (109-917): 3.82e-65: 241: 11.54
+	Hs
		147385 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		PRLR_HUMAN (124-331): 1.44e-44: 173: 25.46
+	Hs
		146590 SOCS2_HUMAN (3-221): 5.64e-48: 158: 28.31		PRLR_HUMAN (124-331): 1.44e-44: 173: 25.46
+	Hs
		560479 CISH_HUMAN (13-225): 1.2e-43: 148: 28.37		PRLR_HUMAN (124-331): 1.44e-44: 173: 25.46
+	Hs
		560471 VAV2_HUMAN (13-205): 3.23e-39: 145: 13.92		PRLR_HUMAN (124-331): 1.44e-44: 173: 25.46
+	Hs
		548629 VAV_HUMAN (4-207): 1.17e-35: 134: 12.75		PRLR_HUMAN (124-331): 1.44e-44: 173: 25.46
+	Hs
		362705 YES_HUMAN (34-179): 1.03e-37: 139: 18.30		FINC_HUMAN (53-592): 6.06e-32: 137: 13.70
+	Mm
		193379 SOCS3_MOUSE (1-225): 1.74e-58: 185: 100.00		LEPR_MOUSE (4-790): 1.98e-17: 89.6: 14.59
+	Hs
		362685 FYN_HUMAN (34-177): 1.34e-35: 133: 20.53		FINC_HUMAN (53-592): 6.06e-32: 137: 13.70
+	Hs
		147403 SOCS3_HUMAN (1-225): 1.97e-56: 180: 96.89		LEPR_HUMAN (293-790): 1.34e-14: 80.8: 14.21
+	Mm
		193361 SOCS2_MOUSE (3-221): 1.44e-48: 159: 28.31		LEPR_MOUSE (4-790): 1.98e-17: 89.6: 14.59
+	Mm
		817309 SOCS6_MOUSE (8-220): 4.11e-43: 153: 23.39		LEPR_MOUSE (4-790): 1.98e-17: 89.6: 14.59
+	Mm
		817306 CISH_MOUSE (14-225): 1.01e-44: 151: 29.95		LEPR_MOUSE (4-790): 1.98e-17: 89.6: 14.59
+	Mm
		817307 SOCS7_MOUSE (16-221): 2.42e-38: 141: 25.24		LEPR_MOUSE (4-790): 1.98e-17: 89.6: 14.59
+	Hs
		855816 VAV2_HUMAN (13-205): 3.23e-39: 145: 13.92		TITIN_HUMAN (23-310): 9.97e-09: 62: 8.59