HitPredict

Interactor 1: RING1 (O35730)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Transcription repressor Ring1A)
Gene: RING1

Interactor 2: KDM2B (Q6P1G2)
Lysine-specific demethylase 2B (EC 1.14.11.27) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) ([Histone-H3]-lysine-36 demethylase 1B)
Gene: KDM2B

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	17296600
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0031519 - PcG protein complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 406 Mm			1 1309
+	Hs
		987996 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		KDM2B_HUMAN (12-1309): 0: 1287: 94.38
+	Mm
		1158239 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		KDM2B_MOUSE (1-1309): 0: 1305: 100.00
+	Hs
		1245587 RING2_HUMAN (8-406): 3.35e-98: 298: 54.25		KDM2B_HUMAN (12-1309): 0: 1287: 94.38
+	Hs
		718413 PCGF2_HUMAN (31-378): 9.27e-64: 209: 16.67		KDM2B_HUMAN (12-1309): 0: 1287: 94.38
+	Mm
		639474 BMI1_MOUSE (31-370): 1.41e-49: 172: 14.87		KDM2B_MOUSE (1-1309): 0: 1305: 100.00
+	Hs
		718034 BMI1_HUMAN (31-370): 4.27e-51: 176: 15.07		KDM2B_HUMAN (12-1309): 0: 1287: 94.38
+	Mm
		1158236 PCGF1_MOUSE (25-130): 1.16e-38: 141: 24.77		KDM2B_MOUSE (1-1309): 0: 1305: 100.00
+	Hs
		1108521 PCGF3_HUMAN (34-273): 3.39e-39: 142: 16.33		KDM2B_HUMAN (12-1309): 0: 1287: 94.38
+	Hs
		1245590 PCGF1_HUMAN (25-130): 8.93e-39: 141: 24.77		KDM2B_HUMAN (12-1309): 0: 1287: 94.38
+	Hs
		1197574 PCGF5_HUMAN (31-147): 5.49e-37: 137: 23.33		KDM2B_HUMAN (12-1309): 0: 1287: 94.38
+	Dm
		1361711 RING1_DROME (1-403): 1.54e-71: 232: 35.46		JHD1_DROME (9-1296): 0: 810: 28.06
+	Hs
		718320 BMI1_HUMAN (31-370): 4.27e-51: 176: 15.07		PHF8_HUMAN (14-481): 7.06e-158: 504: 33.26
+	Hs
		1261312 RN138_HUMAN (31-195): 4.78e-37: 136: 15.79		PHF8_HUMAN (14-481): 7.06e-158: 504: 33.26
+	Hs
		975311 RING2_HUMAN (8-406): 3.35e-98: 298: 54.25		KMT2A_HUMAN (344-837): 2.1e-55: 215: 13.71
+	Hs
		717733 BMI1_HUMAN (31-370): 4.27e-51: 176: 15.07		KMT2A_HUMAN (344-837): 2.1e-55: 215: 13.71
+	Hs
		1311563 PCGF1_HUMAN (25-130): 8.93e-39: 141: 24.77		KDM2A_HUMAN (818-1309): 5.68e-64: 240: 42.02
+	Hs
		718044 BMI1_HUMAN (31-370): 4.27e-51: 176: 15.07		FBX41_HUMAN (716-1271): 7.57e-52: 200: 14.87
+	Hs
		1031260 BARD1_HUMAN (4-352): 2.59e-50: 183: 15.55		SKP2_HUMAN (923-1306): 6.26e-51: 188: 17.26
+	Hs
		1304155 RING2_HUMAN (8-406): 3.35e-98: 298: 54.25		CXXC1_HUMAN (580-624): 5.44e-09: 62.8: 58.70
+	Hs
		584946 RO52_HUMAN (33-307): 1.34e-43: 159: 13.46		SKP2_HUMAN (923-1306): 6.26e-51: 188: 17.26