HitPredict

Interactor 1: CCNE3 (O42575)
G1/S-specific cyclin-E3
Gene: cyce3

Interactor 2: Q91646 (Q91646)
Cyclin-dependent kinase inhibitor p28 (Cyclin-dependent kinase inhibitor xic1 L homeolog) (LOC100137657 protein)
Gene: cdknx.L

Species: Xenopus laevis

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.878

Property	Details
Experiments	8868473, 16118210, 10884410
Identification Methods	affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	CDI~Cyclin_N
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 408 Xl			1 209
+	Xl
		841954 CCNE1_XENLA (1-408): 1.17e-141: 411: 91.42		Q91646_XENLA (1-209): 2.77e-82: 245: 100.00
+	Hs
		624561 CCNE1_HUMAN (5-406): 2.48e-130: 382: 59.51		CDN1B_HUMAN (21-185): 2.33e-52: 168: 25.00
+	Xl
		841953 CCNE1_XENLA (1-408): 1.17e-141: 411: 91.42		Q5V9L9_XENLA (12-188): 5.54e-39: 132: 22.60
+	Hs
		624557 CCNE1_HUMAN (5-406): 2.48e-130: 382: 59.51		CDN1A_HUMAN (27-187): 3.46e-48: 157: 21.95
+	Mm
		803843 CCNE1_MOUSE (1-406): 7.13e-124: 366: 57.39		CDN1B_MOUSE (21-185): 5.23e-51: 165: 26.19
+	Hs
		87258 C9J2U0_HUMAN (13-406): 2.66e-111: 332: 54.41		CDN1A_HUMAN (27-187): 3.46e-48: 157: 21.95
+	Hs
		303836 CCNB2_HUMAN (3-364): 4.69e-103: 312: 20.00		CDN1B_HUMAN (21-185): 2.33e-52: 168: 25.00
+	Mm
		624384 CCNB1_MOUSE (1-361): 2.56e-101: 309: 19.57		CDN1A_MOUSE (27-187): 1.71e-53: 170: 23.60
+	Hs
		331632 CCNE2_HUMAN (4-401): 3.49e-102: 310: 44.50		CDN1B_HUMAN (21-185): 2.33e-52: 168: 25.00
+	Hs
		804103 CCNA1_HUMAN (7-369): 1.29e-98: 303: 20.70		CDN1B_HUMAN (21-185): 2.33e-52: 168: 25.00
+	Hs
		538492 CCNB1_HUMAN (56-369): 1.39e-98: 302: 21.50		CDN1B_HUMAN (21-185): 2.33e-52: 168: 25.00
+	Mm
		763418 CCNA1_MOUSE (7-360): 4.69e-98: 300: 22.04		CDN1A_MOUSE (27-187): 1.71e-53: 170: 23.60
+	Hs
		303835 CCNB2_HUMAN (3-364): 4.69e-103: 312: 20.00		CDN1A_HUMAN (27-187): 3.46e-48: 157: 21.95
+	Hs
		331630 CCNE2_HUMAN (4-401): 3.49e-102: 310: 44.50		CDN1A_HUMAN (27-187): 3.46e-48: 157: 21.95
+	Hs
		758186 CCNA1_HUMAN (7-369): 1.29e-98: 303: 20.70		CDN1A_HUMAN (27-187): 3.46e-48: 157: 21.95
+	Hs
		538489 CCNB1_HUMAN (56-369): 1.39e-98: 302: 21.50		CDN1A_HUMAN (27-187): 3.46e-48: 157: 21.95
+	Hs
		758294 Q8WUE3_HUMAN (4-375): 2.42e-97: 297: 45.04		CDN1A_HUMAN (27-187): 3.46e-48: 157: 21.95
+	Hs
		303838 CCNB2_HUMAN (3-364): 4.69e-103: 312: 20.00		CDN1C_HUMAN (27-137): 4.82e-28: 109: 31.30
+	Hs
		331633 CCNE2_HUMAN (4-401): 3.49e-102: 310: 44.50		CDN1C_HUMAN (27-137): 4.82e-28: 109: 31.30
+	Hs
		538496 CCNB1_HUMAN (56-369): 1.39e-98: 302: 21.50		CDN1C_HUMAN (27-137): 4.82e-28: 109: 31.30