HitPredict

Interactor 1: APC10 (O42971)
Anaphase-promoting complex subunit 10 (20S cyclosome/APC complex protein apc10)
Gene: APC10

Interactor 2: APC3 (P10505)
Anaphase-promoting complex subunit 3 (20S cyclosome/APC complex protein apc3) (Nuclear alteration protein 2) (Nuclear scaffold-like protein p76)
Gene: nuc2

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	9736616, 16950791
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	ANAPC10~TPR_1, ANAPC10~TPR_8
Common GO terms	GO:0005634 - nucleus GO:0005680 - anaphase-promoting complex GO:0031145 - anaphase-promoting complex-dependent catabolic process GO:0051301 - cell division
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 189 Sp			1 665
+	At
		989584 APC10_ARATH (22-189): 2.41e-78: 233: 41.42		CD27A_ARATH (1-650): 1.12e-77: 264: 25.59
+	Sc
		561124 APC10_YEAST (23-173): 7.1e-58: 183: 35.53		CDC23_YEAST (329-641): 6.8e-84: 278: 24.07
+	Hs
		1219389 CUL9_HUMAN (21-187): 5.98e-57: 194: 20.00		APC7_HUMAN (145-664): 3.26e-66: 229: 17.70
+	At
		71754 APC10_ARATH (22-189): 2.41e-78: 233: 41.42		CDC16_ARATH (208-635): 9.4e-40: 155: 15.16
+	Hs
		1023024 APC10_HUMAN (15-189): 6.39e-74: 222: 40.00		CDC16_HUMAN (3-508): 2.44e-32: 134: 14.23
+	At
		1257917 APC10_ARATH (22-189): 2.41e-78: 233: 41.42		APC7_ARATH (308-645): 1.43e-27: 119: 18.31
+	Hs
		1022935 CUL9_HUMAN (21-187): 5.98e-57: 194: 20.00		CDC16_HUMAN (3-508): 2.44e-32: 134: 14.23
+	At
		1352813 APC10_ARATH (22-189): 2.41e-78: 233: 41.42		CDC23_ARATH (35-495): 1.05e-17: 88.8: 13.45
+	At
		1228173 APC10_ARATH (22-189): 2.41e-78: 233: 41.42		CD27B_ARATH (138-428): 1.61e-10: 66.4: 11.00
+	Hs
		672927 APC10_HUMAN (15-189): 6.39e-74: 222: 40.00		CDC27_HUMAN (4-331): 2.28e-13: 75.7: 11.65
+	At
		78419 APC10_ARATH (22-189): 2.41e-78: 233: 41.42		VIP6_ARATH (458-632): 1.37e-09: 63.7: 13.00
+	Hs
		1356117 APC10_HUMAN (15-189): 6.39e-74: 222: 40.00		CDC23_HUMAN (369-637): 5.58e-11: 67.6: 13.07
+	Xl
		1125463 Q5EAZ2_XENLA (18-189): 2.97e-72: 218: 40.12		Q6GQ04_XENLA (12-331): 1.88e-09: 62.9: 12.99
+	Hs
		672859 CUL9_HUMAN (21-187): 5.98e-57: 194: 20.00		CDC27_HUMAN (4-331): 2.28e-13: 75.7: 11.65
+	Hs
		684730 CUL7_HUMAN (21-187): 1.17e-57: 196: 20.59		STIP1_HUMAN (536-665): 3.43e-11: 68.3: 13.53
+	Hs
		1219388 CUL9_HUMAN (21-187): 5.98e-57: 194: 20.00		CDC23_HUMAN (369-637): 5.58e-11: 67.6: 13.07
+	Sc
		743219 APC10_YEAST (23-173): 7.1e-58: 183: 35.53		CDC27_YEAST (15-184): 4.41e-09: 61.8: 13.47