HitPredict

Interactor 1: DHX15 (O43143)
ATP-dependent RNA helicase DHX15 (EC 3.6.4.13) (ATP-dependent RNA helicase #46) (DEAH box protein 15) (Splicing factor Prp43) (hPrp43)
Gene: DHX15

Interactor 2: RBM10 (P98175)
RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1)
Gene: RBM10

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.808

Property	Details
Experiments	22365833, 29021621
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	G-patch~HA2, G-patch~Helicase_C, G-patch~OB_NTP_bind
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 795 Hs			1 930
+	Hs
		195384 DHX15_HUMAN (1-795): 0: 856: 100.00		RBM5_HUMAN (1-930): 2.77e-135: 426: 47.80
+	Hs
		958025 DHX8_HUMAN (16-783): 0: 757: 45.46		RBM10_HUMAN (1-930): 2.52e-168: 516: 100.00
+	Hs
		958093 PRP16_HUMAN (10-781): 0: 741: 39.48		RBM10_HUMAN (1-930): 2.52e-168: 516: 100.00
+	Hs
		856066 DHX8_HUMAN (16-783): 0: 757: 45.46		RBM5_HUMAN (1-930): 2.77e-135: 426: 47.80
+	Hs
		195482 DHX15_HUMAN (1-795): 0: 856: 100.00		SUGP1_HUMAN (591-927): 6.31e-66: 235: 17.07
+	Hs
		195488 DHX15_HUMAN (1-795): 0: 856: 100.00		AGGF1_HUMAN (442-757): 3.72e-50: 191: 18.55
+	Hs
		1055419 DHX8_HUMAN (16-783): 0: 757: 45.46		SUGP1_HUMAN (591-927): 6.31e-66: 235: 17.07
+	At
		97489 DEAH2_ARATH (85-793): 0: 797: 68.25		SUA_ARATH (526-929): 4.82e-48: 187: 21.37
+	Hs
		941773 DHX8_HUMAN (16-783): 0: 757: 45.46		RBM6_HUMAN (572-930): 5.8e-50: 193: 32.03
+	Hs
		994182 DHX9_HUMAN (3-764): 0: 599: 23.31		ELAV1_HUMAN (289-448): 4.76e-20: 94.2: 18.41