HitPredict

Interactor 1: DHX15 (O43143)
ATP-dependent RNA helicase DHX15 (EC 3.6.4.13) (ATP-dependent RNA helicase #46) (DEAH box protein 15) (Splicing factor Prp43) (hPrp43)
Gene: DHX15

Interactor 2: TFP11 (Q9UBB9)
Tuftelin-interacting protein 11 (Septin and tuftelin-interacting protein 1) (STIP-1)
Gene: TFIP11

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.805

Property	Details
Experiments	27798625, 29021621, 24304693
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	G-patch~HA2, G-patch~Helicase_C, G-patch~OB_NTP_bind
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005654 - nucleoplasm GO:0005681 - spliceosomal complex GO:0005730 - nucleolus GO:0016607 - nuclear speck
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 795 Hs			1 837
+	Mm
		192555 DHX15_MOUSE (1-795): 0: 851: 99.62		TFP11_MOUSE (1-837): 0: 1108: 92.12
+	Hs
		1055498 DHX8_HUMAN (16-783): 0: 757: 45.46		TFP11_HUMAN (1-837): 0: 1109: 100.00
+	Hs
		224856 DHX16_HUMAN (10-789): 0: 736: 44.72		TFP11_HUMAN (1-837): 0: 1109: 100.00
+	Sp
		194935 DHX15_SCHPO (72-793): 0: 748: 59.64		YKR3_SCHPO (42-835): 0: 697: 23.37
+	Sc
		859436 PRP43_YEAST (47-792): 0: 740: 59.89		SP382_YEAST (281-829): 4.9e-160: 484: 16.07
+	Hs
		195490 DHX15_HUMAN (1-795): 0: 856: 100.00		ZGPAT_HUMAN (41-361): 5.71e-79: 266: 16.19
+	Hs
		3460 DHX15_HUMAN (1-795): 0: 856: 100.00		A0A0S2Z6H0_HUMAN (41-361): 1.62e-78: 265: 15.79