HitPredict

Interactor 1: FLRT2 (O43155)
Leucine-rich repeat transmembrane protein FLRT2 (Fibronectin-like domain-containing leucine-rich transmembrane protein 2)
Gene: FLRT2

Interactor 2: UNC5D (Q6UXZ4)
Netrin receptor UNC5D (Protein unc-5 homolog 4) (Protein unc-5 homolog D)
Gene: UNC5D

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21673655
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	I-set~fn3, I-set~LRR_8, LRR_8~TSP_1
Common GO terms	GO:0005886 - plasma membrane GO:0007411 - axon guidance GO:2001222 - regulation of neuron migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 660 Hs			1 953
+	Mm
		1206870 FLRT2_MOUSE (1-660): 6.56e-140: 425: 97.27		UNC5D_MOUSE (1-953): 0: 871: 95.72
+	Mm
		1164191 FLRT1_MOUSE (16-660): 1.11e-122: 381: 42.81		UNC5D_MOUSE (1-953): 0: 871: 95.72
+	Mm
		1206871 FLRT2_MOUSE (1-660): 6.56e-140: 425: 97.27		UNC5B_MOUSE (10-939): 0: 806: 51.27
+	Mm
		139751 FLRT2_MOUSE (1-660): 6.56e-140: 425: 97.27		UNC5C_MOUSE (18-939): 0: 781: 49.79
+	Hs
		1224475 FLRT3_HUMAN (9-660): 3.5e-123: 381: 44.06		UNC5B_HUMAN (8-939): 0: 823: 52.65
+	Mm
		1164192 FLRT1_MOUSE (16-660): 1.11e-122: 381: 42.81		UNC5B_MOUSE (10-939): 0: 806: 51.27
+	Mm
		1206872 FLRT2_MOUSE (1-660): 6.56e-140: 425: 97.27		UNC5A_MOUSE (26-939): 0: 746: 44.67
+	Mm
		139750 FLRT1_MOUSE (16-660): 1.11e-122: 381: 42.81		UNC5C_MOUSE (18-939): 0: 781: 49.79
+	Dr
		69121 B8A507_DANRE (22-660): 3.28e-123: 381: 45.34		A9JR35_DANRE (33-939): 0: 754: 48.48
+	Mm
		1164193 FLRT1_MOUSE (16-660): 1.11e-122: 381: 42.81		UNC5A_MOUSE (26-939): 0: 746: 44.67
+	Dr
		47569 A0A8M9PLL4_DANRE (36-660): 5.94e-109: 346: 38.27		A9JR35_DANRE (33-939): 0: 754: 48.48
+	Dr
		69122 F1QF54_DANRE (21-258): 3.87e-27: 119: 23.86		A9JR35_DANRE (33-939): 0: 754: 48.48
+	Hs
		616984 LRRN1_HUMAN (17-647): 5.18e-89: 294: 18.50		PTPRD_HUMAN (49-818): 4.68e-37: 154: 12.05
+	Mm
		1194740 LRC4C_MOUSE (36-582): 5.49e-71: 243: 20.43		AGRB3_MOUSE (162-418): 3.68e-49: 192: 25.00
+	Hs
		200339 LRRT2_HUMAN (1-389): 1.21e-75: 253: 24.43		PTPRD_HUMAN (49-818): 4.68e-37: 154: 12.05
+	Hs
		616988 LIGO2_HUMAN (11-359): 1.8e-73: 250: 23.27		PTPRD_HUMAN (49-818): 4.68e-37: 154: 12.05
+	Dr
		82309 B8JKM0_DANRE (6-454): 3.23e-83: 273: 21.30		Q90Z70_DANRE (23-267): 1.06e-29: 130: 17.38
+	Dr
		47580 B8JKM0_DANRE (6-454): 3.23e-83: 273: 21.30		A0A8M9QLH5_DANRE (23-267): 2.45e-29: 128: 17.38
+	Hs
		259496 LRRN2_HUMAN (13-518): 2.22e-64: 227: 18.30		PTPRD_HUMAN (49-818): 4.68e-37: 154: 12.05
+	Mm
		1112554 LRC4C_MOUSE (36-582): 5.49e-71: 243: 20.43		AGRB1_MOUSE (124-384): 1.45e-26: 119: 21.11