HitPredict

Interactor 1: TTI1 (O43156)
TELO2-interacting protein 1 homolog (Protein SMG10)
Gene: TTI1

Interactor 2: PRKDC (P78527)
DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460)
Gene: PRKDC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	20810650, 20427287, 20371770
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1089 Hs			1 4128
+	Hs
		195955 TTI1_HUMAN (1-1089): 0: 1217: 100.00		TRRAP_HUMAN (2754-4128): 0: 828: 15.88
+	Hs
		195892 TTI1_HUMAN (1-1089): 0: 1217: 100.00		MTOR_HUMAN (2776-4127): 0: 695: 15.99
+	At
		96186 F4IDJ4_ARATH (62-1062): 0: 790: 17.34		TOR_ARATH (2776-4127): 0: 1008: 18.71
+	Hs
		195905 TTI1_HUMAN (1-1089): 0: 1217: 100.00		ATM_HUMAN (3218-4128): 1.84e-158: 557: 19.42
+	Hs
		195935 TTI1_HUMAN (1-1089): 0: 1217: 100.00		SMG1_HUMAN (3179-4115): 6.6e-124: 444: 16.20
+	Hs
		195907 TTI1_HUMAN (1-1089): 0: 1217: 100.00		ATR_HUMAN (3377-4128): 2.05e-122: 438: 19.28
+	Dm
		1366743 Q9VH80_DROME (14-1046): 0: 920: 20.66		TOR_DROME (2776-4127): 0: 727: 18.28
+	Sp
		293733 TTI1_SCHPO (22-1082): 0: 788: 18.28		TOR2_SCHPO (2776-4127): 0: 755: 18.22
+	Dm
		1211951 Q9VH80_DROME (14-1046): 0: 920: 20.66		TRA1_DROME (2785-4128): 1.74e-164: 578: 15.78
+	Sp
		145535 TTI1_SCHPO (22-1082): 0: 788: 18.28		TOR1_SCHPO (2776-4127): 0: 695: 17.19
+	Sc
		715177 TTI1_YEAST (30-1043): 0: 762: 17.34		TOR1_YEAST (2759-4127): 0: 677: 15.92
+	Sp
		251726 TTI1_SCHPO (22-1082): 0: 788: 18.28		ATM_SCHPO (3300-4127): 2.77e-117: 422: 18.74
+	Sp
		293730 TTI1_SCHPO (22-1082): 0: 788: 18.28		TRA1_SCHPO (2790-4128): 5.48e-113: 408: 14.80
+	Sp
		293727 TTI1_SCHPO (22-1082): 0: 788: 18.28		RAD3_SCHPO (3345-4127): 1.56e-112: 406: 15.70
+	Sp
		293728 TTI1_SCHPO (22-1082): 0: 788: 18.28		YAMB_SCHPO (2923-4128): 5.23e-108: 392: 14.25
+	Sc
		732564 TTI1_YEAST (30-1043): 0: 762: 17.34		TRA1_YEAST (2924-4127): 1.79e-115: 416: 14.57