HitPredict

Interactor 1: TTI1 (O43156)
TELO2-interacting protein 1 homolog (Protein SMG10)
Gene: TTI1

Interactor 2: ATM (Q13315)
Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated)
Gene: ATM

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.677

Property	Details
Experiments	20810650, 34838521, 20427287
Identification Methods	affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1089 Hs			1 3056
+	Hs
		195907 TTI1_HUMAN (1-1089): 0: 1217: 100.00		ATR_HUMAN (1223-3056): 0: 1214: 20.34
+	Hs
		195892 TTI1_HUMAN (1-1089): 0: 1217: 100.00		MTOR_HUMAN (1846-3055): 0: 843: 16.65
+	Hs
		195955 TTI1_HUMAN (1-1089): 0: 1217: 100.00		TRRAP_HUMAN (1874-3056): 0: 683: 12.97
+	Sp
		293727 TTI1_SCHPO (22-1082): 0: 788: 18.28		RAD3_SCHPO (1153-3055): 0: 1006: 18.02
+	Hs
		195901 TTI1_HUMAN (1-1089): 0: 1217: 100.00		PRKDC_HUMAN (2005-3056): 6.86e-155: 545: 17.20
+	Dm
		1366743 Q9VH80_DROME (14-1046): 0: 920: 20.66		TOR_DROME (1644-3055): 0: 829: 17.31
+	Sp
		293733 TTI1_SCHPO (22-1082): 0: 788: 18.28		TOR2_SCHPO (1850-3055): 0: 864: 17.30
+	Sp
		145535 TTI1_SCHPO (22-1082): 0: 788: 18.28		TOR1_SCHPO (1851-3055): 0: 829: 18.20
+	Sc
		715177 TTI1_YEAST (30-1043): 0: 762: 17.34		TOR1_YEAST (1500-3055): 0: 846: 16.38
+	Dm
		1211951 Q9VH80_DROME (14-1046): 0: 920: 20.66		TRA1_DROME (1871-3056): 0: 675: 13.65
+	At
		96186 F4IDJ4_ARATH (62-1062): 0: 790: 17.34		TOR_ARATH (1615-3055): 0: 778: 16.94
+	Hs
		195935 TTI1_HUMAN (1-1089): 0: 1217: 100.00		SMG1_HUMAN (2626-2961): 7.72e-90: 331: 29.12
+	Sp
		251726 TTI1_SCHPO (22-1082): 0: 788: 18.28		ATM_SCHPO (1689-3055): 0: 696: 25.11
+	Sc
		732564 TTI1_YEAST (30-1043): 0: 762: 17.34		TRA1_YEAST (1749-3055): 0: 683: 13.08
+	Sp
		293730 TTI1_SCHPO (22-1082): 0: 788: 18.28		TRA1_SCHPO (1748-3056): 3.57e-176: 613: 12.83
+	Sp
		293728 TTI1_SCHPO (22-1082): 0: 788: 18.28		YAMB_SCHPO (1225-3056): 5.79e-167: 584: 12.71