HitPredict

Interactor 1: PLXB1 (O43157)
Plexin-B1 (Semaphorin receptor SEP)
Gene: PLXNB1

Interactor 2: SEM4D (Q92854)
Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100)
Gene: SEMA4D

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.64 1.00 0.802

The method score is based on:

Property Details
Experiments 11937491, 20877282
Identification Methods affinity chromatography technology, molecular sieving, surface plasmon resonance, x-ray crystallography
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains PSI~ig, PSI~Sema, Sema~Sema, PSI~TIG, Sema~TIG, PSI~TIG_2, PSI~TIG_plexin, Sema~TIG_plexin
Common GO terms GO:0002116 - semaphorin receptor complex
GO:0004888 - transmembrane signaling receptor activity
GO:0005886 - plasma membrane
GO:0007162 - negative regulation of cell adhesion
GO:0008360 - regulation of cell shape
and 6 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

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Hs

1 862
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Last updated: 15 Jul 2024