HitPredict - High confidence protein-protein interactions

Interactor 1: IRAK2 (O43187)
Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)
Gene: IRAK2

Interactor 2: IRAK2 (O43187)
Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)
Gene: IRAK2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	10383454
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Death~Death, Pkinase~Pkinase
Common GO terms	GO:0001959 - regulation of cytokine-mediated signaling pathway GO:0002755 - MyD88-dependent toll-like receptor signaling pathway GO:0004672 - protein kinase activity GO:0005524 - ATP binding GO:0005634 - nucleus and 20 others more... GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006468 - protein phosphorylation GO:0006954 - inflammatory response GO:0007249 - canonical NF-kappaB signal transduction GO:0008063 - Toll signaling pathway GO:0010008 - endosome membrane GO:0031663 - lipopolysaccharide-mediated signaling pathway GO:0032088 - negative regulation of NF-kappaB transcription factor activity GO:0034142 - toll-like receptor 4 signaling pathway GO:0035556 - intracellular signal transduction GO:0035591 - signaling adaptor activity GO:0042803 - protein homodimerization activity GO:0046982 - protein heterodimerization activity GO:0051092 - positive regulation of NF-kappaB transcription factor activity GO:0060090 - molecular adaptor activity GO:0070498 - interleukin-1-mediated signaling pathway GO:0070555 - response to interleukin-1 GO:0071222 - cellular response to lipopolysaccharide
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1	625
Hs

1	625

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Last updated: 15 Jul 2024