HitPredict

Interactor 1: IRAK2 (O43187)
Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)
Gene: IRAK2

Interactor 2: TIRAP (P58753)
Toll/interleukin-1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (Adaptor protein Wyatt) (MyD88 adapter-like protein) (MyD88-2)
Gene: TIRAP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

The method score is based on:

Property	Details
Experiments	11544529, 21903422
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002755 - MyD88-dependent toll-like receptor signaling pathway GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006954 - inflammatory response and 5 others more... GO:0007249 - canonical NF-kappaB signal transduction GO:0034142 - toll-like receptor 4 signaling pathway GO:0035591 - signaling adaptor activity GO:0051092 - positive regulation of NF-kappaB transcription factor activity GO:0060090 - molecular adaptor activity
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	625
Hs

1	221

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024