HitPredict

Interactor 1: PSMD3 (O43242)
26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58)
Gene: PSMD3

Interactor 2: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	32929329, 35509820, 35256949, 23503661
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 534 Hs			1 465
+	Hs
		198528 PSMD3_HUMAN (1-534): 0: 642: 100.00		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		229065 CSN3_HUMAN (226-511): 1.4e-95: 298: 20.54		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	At
		1092162 PSD3B_ARATH (33-533): 0: 575: 42.66		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		1092148 PSD3A_ARATH (33-533): 0: 574: 43.96		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Sc
		477298 RPN3_YEAST (45-531): 1.11e-166: 484: 30.87		UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72
+	Hs
		476573 CSN3_HUMAN (226-511): 1.4e-95: 298: 20.54		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47