HitPredict

Interactor 1: PSMD3 (O43242)
26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58)
Gene: PSMD3

Interactor 2: PSA3 (P25788)
Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8)
Gene: PSMA3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 534 Hs			1 255
+	Hs
		198550 PSMD3_HUMAN (1-534): 0: 642: 100.00		PSA5_HUMAN (1-239): 4.52e-96: 283: 31.97
+	Hs
		198592 PSMD3_HUMAN (1-534): 0: 642: 100.00		PSA6_HUMAN (4-242): 1.96e-95: 281: 29.34
+	Hs
		198546 PSMD3_HUMAN (1-534): 0: 642: 100.00		PSA4_HUMAN (4-236): 5.31e-94: 278: 27.43
+	Hs
		156172 PSMD3_HUMAN (1-534): 0: 642: 100.00		PSA7_HUMAN (7-237): 4.58e-93: 275: 31.76
+	Sc
		597245 RPN3_YEAST (45-531): 1.11e-166: 484: 30.87		PSA7_YEAST (1-246): 4.1e-111: 322: 51.20
+	Sc
		689184 RPN3_YEAST (45-531): 1.11e-166: 484: 30.87		PSA5_YEAST (1-255): 3.35e-94: 278: 32.57
+	Sp
		194817 RPN3_SCHPO (37-534): 0: 545: 42.60		PSA4_SCHPO (6-189): 3.96e-35: 127: 40.00
+	Sc
		619361 RPN3_YEAST (45-531): 1.11e-166: 484: 30.87		PSA3_YEAST (8-198): 2.62e-34: 125: 35.42