HitPredict

Interactor 1: PSMD3 (O43242)
26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58)
Gene: PSMD3

Interactor 2: PSMD8 (P48556)
26S proteasome non-ATPase regulatory subunit 8 (26S proteasome regulatory subunit RPN12) (26S proteasome regulatory subunit S14) (p31)
Gene: PSMD8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.946

The method score is based on:

Property	Details
Experiments	37071682, 18775730, 28292943, 33961781, 34349018, 35235311
Identification Methods	cross-linking study, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	CSN8_PSD8_EIF3K~PCI, CSN8_PSD8_EIF3K~Rpn3_C
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0008541 - proteasome regulatory particle, lid subcomplex and 2 others more... GO:0022624 - proteasome accessory complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	534
Hs

1	350

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024