HitPredict

Interactor 1: PSMD3 (O43242)
26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58)
Gene: PSMD3

Interactor 2: PSMD1 (Q99460)
26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112)
Gene: PSMD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.866

The method score is based on:

Property	Details
Experiments	28292943, 33961781, 35271311
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	HEAT_2~Rpn3_C
Common GO terms	GO:0000502 - proteasome complex GO:0005576 - extracellular region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol and 5 others more... GO:0016020 - membrane GO:0022624 - proteasome accessory complex GO:0030234 - enzyme regulator activity GO:0042176 - regulation of protein catabolic process GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	534
Hs

1	953

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024