HitPredict

Interactor 1: PSMD3 (O43242)
26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58)
Gene: PSMD3

Interactor 2: UBQL1 (Q9UMX0)
Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)
Gene: UBQLN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	27114451, 15147878
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 534 Hs			1 589
+	Hs
		198746 PSMD3_HUMAN (1-534): 0: 642: 100.00		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Mm
		539514 PSMD3_MOUSE (1-534): 0: 633: 96.26		UBQL2_MOUSE (1-589): 8.33e-141: 424: 65.47
+	Hs
		198730 PSMD3_HUMAN (1-534): 0: 642: 100.00		UBQL4_HUMAN (28-589): 1.35e-135: 409: 57.64
+	Dm
		627146 PSMD3_DROME (40-533): 0: 562: 57.49		Q9VWD9_DROME (30-582): 3.32e-135: 407: 47.39
+	Hs
		198677 PSMD3_HUMAN (1-534): 0: 642: 100.00		DDI1_HUMAN (47-318): 6.39e-53: 187: 15.60
+	Hs
		198650 PSMD3_HUMAN (1-534): 0: 642: 100.00		DDI2_HUMAN (47-318): 2.03e-49: 178: 13.52
+	Hs
		198601 PSMD3_HUMAN (1-534): 0: 642: 100.00		RS27A_HUMAN (37-123): 1.1e-12: 68: 30.68
+	Sc
		697087 RPN3_YEAST (45-531): 1.11e-166: 484: 30.87		RAD23_YEAST (45-419): 1.17e-31: 128: 17.73