HitPredict

Interactor 1: RFOX2 (O43251)
RNA binding protein fox-1 homolog 2 (Fox-1 homolog B) (Hexaribonucleotide-binding protein 2) (RNA-binding motif protein 9) (RNA-binding protein 9) (Repressor of tamoxifen transcriptional activity)
Gene: RBFOX2

Interactor 2: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.573

Property	Details
Experiments	11875103
Identification Methods	pull down, two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0030520 - estrogen receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 390 Hs			1 595
+	Hs
		369663 SAFB1_HUMAN (14-214): 5.77e-42: 159: 21.36		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		369583 SAFB2_HUMAN (14-203): 1.29e-41: 158: 20.51		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		369534 PABP4_HUMAN (22-287): 1.65e-36: 142: 13.87		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		368886 PABP1_HUMAN (22-296): 2.88e-35: 138: 15.55		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		370176 PABP5_HUMAN (16-200): 1.51e-31: 125: 14.57		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		369064 TIA1_HUMAN (116-302): 3.44e-26: 110: 19.17		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		198946 RFOX2_HUMAN (1-390): 1.43e-65: 215: 100.00		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		1073538 SAFB1_HUMAN (14-214): 5.77e-42: 159: 21.36		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		1049498 SAFB2_HUMAN (14-203): 1.29e-41: 158: 20.51		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		198825 RFOX2_HUMAN (1-390): 1.43e-65: 215: 100.00		GCR_HUMAN (5-557): 4.67e-109: 346: 22.51
+	Hs
		1269750 RFOX1_HUMAN (19-390): 3.82e-40: 148: 59.46		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		1031409 PABP4_HUMAN (22-287): 1.65e-36: 142: 13.87		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		1269332 PABP5_HUMAN (16-200): 1.51e-31: 125: 14.57		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		782537 PABP4_HUMAN (22-287): 1.65e-36: 142: 13.87		HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58
+	Hs
		740523 SAFB2_HUMAN (14-203): 1.29e-41: 158: 20.51		PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35
+	Hs
		611434 PABP4_HUMAN (22-287): 1.65e-36: 142: 13.87		NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54
+	Hs
		516359 PABP1_HUMAN (22-296): 2.88e-35: 138: 15.55		NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54
+	Mm
		509289 PABP1_MOUSE (22-296): 4e-35: 138: 15.55		RARA_MOUSE (81-545): 8.36e-104: 323: 22.37
+	Hs
		487460 SAFB1_HUMAN (14-214): 5.77e-42: 159: 21.36		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		487081 PABP1_HUMAN (22-296): 2.88e-35: 138: 15.55		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16