HitPredict

Interactor 1: BRI1 (O22476)
Protein BRASSINOSTEROID INSENSITIVE 1 (AtBRI1) (EC 2.7.10.1) (EC 2.7.11.1) (Brassinosteroid LRR receptor kinase)
Gene: BRI1

Interactor 2: BAK1 (Q94F62)
BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 (AtBAK1) (BRI1-associated receptor kinase 1) (EC 2.7.10.1) (EC 2.7.11.1) (Protein ELONGATED) (Somatic embryogenesis receptor kinase 3) (AtSERK3) (Somatic embryogenesis receptor-like kinase 3)
Gene: BAK1

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.986

Property	Details
Experiments	19532123, 19277500, 12150929, 21464298, 24126715, 18332904, 18694562, 15894717, 15548744, 12150928, 21593986, 22087006, 22184234, 29320478
Identification Methods	affinity chromatography technology, enzymatic study, pull down, two hybrid, x-ray crystallography, fluorescent resonance energy transfer, anti tag coimmunoprecipitation, solid phase assay, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Island~LRR_1, Island~LRR_8, Island~LRRNT_2, LRR_1~LRR_1, LRR_1~LRR_8, LRRNT_2~LRR_1, LRR_8~LRR_8, LRRNT_2~LRR_8, LRR_8~PK_Tyr_Ser-Thr, LRRNT_2~LRRNT_2, LRR_8~Pkinase, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0004714 - transmembrane receptor protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0010008 - endosome membrane and 1 others more... GO:0106310 - protein serine kinase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1196 At			1 615
+	At
		198916 BRI1_ARATH (1-1196): 0: 1020: 100.00		SERK1_ARATH (1-615): 0: 685: 77.07
+	At
		198933 BRI1_ARATH (1-1196): 0: 1020: 100.00		SERK4_ARATH (23-615): 0: 667: 81.88
+	At
		89012 BRI1_ARATH (1-1196): 0: 1020: 100.00		Y5129_ARATH (1-615): 0: 653: 54.53
+	At
		1376505 BRL1_ARATH (6-1182): 0: 902: 45.03		BAK1_ARATH (1-615): 0: 729: 100.00
+	At
		198918 BRI1_ARATH (1-1196): 0: 1020: 100.00		Y5838_ARATH (1-586): 0: 547: 30.68
+	At
		1320597 BRL1_ARATH (6-1182): 0: 902: 45.03		SERK5_ARATH (10-615): 0: 642: 74.38
+	At
		1441326 BRL1_ARATH (6-1182): 0: 902: 45.03		NIK1_ARATH (1-615): 0: 641: 50.08
+	At
		1354692 BRL1_ARATH (6-1182): 0: 902: 45.03		Y4052_ARATH (1-611): 0: 629: 47.33
+	At
		89248 EMS1_ARATH (30-1158): 0: 901: 33.64		Y5457_ARATH (1-615): 0: 620: 44.60
+	At
		88110 EMS1_ARATH (30-1158): 0: 901: 33.64		Y1677_ARATH (20-611): 1.09e-179: 534: 28.64
+	At
		1246784 BRL1_ARATH (6-1182): 0: 902: 45.03		SRF8_ARATH (3-597): 5.08e-177: 520: 25.75
+	At
		198902 BRI1_ARATH (1-1196): 0: 1020: 100.00		BAME1_ARATH (12-206): 5.6e-25: 112: 24.20
+	At
		198900 BRI1_ARATH (1-1196): 0: 1020: 100.00		BRI1_ARATH (80-181): 6.31e-13: 74.3: 42.16
+	At
		198919 BRI1_ARATH (1-1196): 0: 1020: 100.00		PSYR1_ARATH (30-181): 6.86e-09: 61.2: 29.88
+	At
		235861 BRL1_ARATH (6-1182): 0: 902: 45.03		BAME1_ARATH (12-206): 5.6e-25: 112: 24.20
+	At
		235840 EMS1_ARATH (30-1158): 0: 901: 33.64		BAME1_ARATH (12-206): 5.6e-25: 112: 24.20
+	At
		1192484 BRL1_ARATH (6-1182): 0: 902: 45.03		ERECT_ARATH (74-181): 1.33e-11: 69.7: 39.82
+	At
		1441652 BRL1_ARATH (6-1182): 0: 902: 45.03		BRL3_ARATH (73-182): 8.47e-10: 63.9: 34.21
+	At
		1422348 BRL1_ARATH (6-1182): 0: 902: 45.03		PSYR1_ARATH (30-181): 6.86e-09: 61.2: 29.88
+	At
		1492059 BRL1_ARATH (6-1182): 0: 902: 45.03		BRL1_ARATH (66-181): 7.15e-09: 61.2: 33.90