Interactor 1: PAPS1 (O43252)
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPS synthase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK 1) (SK1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)]
Gene: PAPSS1

Interactor 2: PAPS2 (O95340)
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPS synthase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK 2) (SK2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)]
Gene: PAPSS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.64 1.00 0.802

The method score is based on:

Property Details
Experiments 33961781, 28514442
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains APS_kinase~APS_kinase, APS_kinase~ATP-sulfurylase, APS_kinase~PUA_2, ATP-sulfurylase~ATP-sulfurylase, ATP-sulfurylase~PUA_2, PUA_2~PUA_2
Common GO terms GO:0000103 - sulfate assimilation
GO:0004020 - adenylylsulfate kinase activity
GO:0004781 - sulfate adenylyltransferase (ATP) activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
and 3 others

more...

Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 624
Hs

1 614
+ Sp
+ Sc
+ At
+ At
+ Cj
+ Sp
+ Zm

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Last updated: 15 Jul 2024