HitPredict

Interactor 1: SIAH2 (O43255)
E3 ubiquitin-protein ligase SIAH2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH2) (Seven in absentia homolog 2) (Siah-2) (hSiah2)
Gene: SIAH2

Interactor 2: SNCAP (Q9Y6H5)
Synphilin-1 (Sph1) (Alpha-synuclein-interacting protein)
Gene: SNCAIP

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.629

Property	Details
Experiments	16174773, 15064394
Identification Methods	enzymatic study, anti tag coimmunoprecipitation
Interaction Type	direct interaction, ubiquitination reaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043025 - neuronal cell body
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 324 Hs			1 919
+	Rn
		88815 SIAH1_RAT (28-322): 2.2e-108: 318: 75.59		D3ZWQ5_RAT (1-919): 0: 561: 85.33
+	Hs
		1216742 SIAH1_HUMAN (28-322): 6.56e-109: 320: 75.25		SNCAP_HUMAN (1-919): 0: 553: 100.00
+	Hs
		1331820 RNF41_HUMAN (64-192): 2.58e-33: 126: 19.85		SNCAP_HUMAN (1-919): 0: 553: 100.00
+	Hs
		129545 TRAF5_HUMAN (63-237): 5.59e-37: 140: 14.72		RIPK4_HUMAN (392-545): 1.53e-10: 67.1: 17.53
+	Hs
		1163035 TRAF7_HUMAN (3-267): 3.47e-36: 139: 15.02		Q9H4D1_HUMAN (392-545): 1.5e-10: 67.1: 17.53
+	Hs
		883544 TRAF7_HUMAN (3-267): 3.47e-36: 139: 15.02		RIPK4_HUMAN (392-545): 1.53e-10: 67.1: 17.53
+	Hs
		883500 TRAF3_HUMAN (18-212): 7.53e-34: 132: 13.11		RIPK4_HUMAN (392-545): 1.53e-10: 67.1: 17.53
+	Hs
		883631 TRAF4_HUMAN (64-212): 1.51e-31: 124: 17.61		RIPK4_HUMAN (392-545): 1.53e-10: 67.1: 17.53