HitPredict

Interactor 1: EFS (O43281)
Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3)
Gene: EFS

Interactor 2: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.743

Property	Details
Experiments	26871637, 31515488
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH3_9~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 561 Hs			1 380
+	Hs
		199501 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24
+	Hs
		3132 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		A0A0S2Z4D7_HUMAN (1-138): 6.51e-59: 190: 67.39
+	Hs
		209112 MINK1_HUMAN (48-378): 5.94e-26: 115: 14.67		NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00
+	Hs
		557691 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24
+	Hs
		209039 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00
+	Mm
		222878 ACK1_MOUSE (11-484): 7.98e-29: 124: 15.31		NCK1_MOUSE (1-379): 6.79e-91: 279: 68.24
+	Hs
		557740 MINK1_HUMAN (48-378): 5.94e-26: 115: 14.67		NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24
+	Hs
		91474 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		E7ERP6_HUMAN (1-76): 8.84e-45: 150: 98.68
+	Hs
		199505 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		P85A_HUMAN (166-379): 4.05e-24: 106: 16.36
+	Hs
		199497 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		FYN_HUMAN (7-137): 2.1e-23: 103: 20.30
+	Hs
		3145 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		A0A0S2Z4E4_HUMAN (1-153): 5.51e-23: 98.3: 60.13
+	Hs
		199508 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		BLK_HUMAN (7-204): 3.35e-19: 91: 19.80
+	Hs
		199510 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81
+	Hs
		199500 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55
+	Hs
		199498 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		YES_HUMAN (6-120): 7.99e-16: 80.8: 23.08
+	Mm
		403448 EFS_MOUSE (1-561): 2.45e-61: 213: 79.50		SRC_MOUSE (6-153): 5.44e-20: 93.3: 17.33
+	Hs
		412193 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		FYN_HUMAN (7-137): 2.1e-23: 103: 20.30
+	Hs
		411721 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53
+	Hs
		411790 MINK1_HUMAN (48-378): 5.94e-26: 115: 14.67		LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53
+	Hs
		924703 MINK1_HUMAN (48-378): 5.94e-26: 115: 14.67		GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81