HitPredict

Interactor 1: EFS (O43281)
Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3)
Gene: EFS

Interactor 2: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 561 Hs			1 1130
+	Hs
		337474 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		ABL1_HUMAN (1-1130): 0: 984: 100.00
+	Hs
		199500 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		SRC_HUMAN (13-510): 0: 547: 38.58
+	Hs
		199497 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		FYN_HUMAN (18-510): 0: 543: 38.64
+	Hs
		199498 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		YES_HUMAN (5-510): 3.73e-179: 537: 39.42
+	Mm
		403448 EFS_MOUSE (1-561): 2.45e-61: 213: 79.50		SRC_MOUSE (13-510): 0: 545: 38.19
+	Hs
		199508 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		BLK_HUMAN (9-508): 4.18e-165: 499: 38.33
+	Mm
		639451 EFS_MOUSE (1-561): 2.45e-61: 213: 79.50		LYN_MOUSE (9-508): 4.68e-172: 517: 35.77
+	Hs
		412193 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		FYN_HUMAN (18-510): 0: 543: 38.64
+	Hs
		411721 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		LCK_HUMAN (9-508): 3.02e-177: 531: 38.49
+	Hs
		297808 K0754_HUMAN (34-464): 4e-33: 137: 13.71		LYN_HUMAN (9-508): 9.12e-173: 519: 36.15
+	Hs
		522936 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		SRC_HUMAN (13-510): 0: 547: 38.58
+	Hs
		64077 L37A2_HUMAN (68-420): 4.98e-23: 106: 17.71		SRC_HUMAN (13-510): 0: 547: 38.58
+	Hs
		412152 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		FYN_HUMAN (18-510): 0: 543: 38.64
+	Hs
		433761 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		LYN_HUMAN (9-508): 9.12e-173: 519: 36.15
+	Hs
		411790 MINK1_HUMAN (48-378): 5.94e-26: 115: 14.67		LCK_HUMAN (9-508): 3.02e-177: 531: 38.49
+	Hs
		433331 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		YES_HUMAN (5-510): 3.73e-179: 537: 39.42
+	Hs
		433891 MINK1_HUMAN (48-378): 5.94e-26: 115: 14.67		LYN_HUMAN (9-508): 9.12e-173: 519: 36.15
+	Hs
		442817 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		HCK_HUMAN (9-508): 5.18e-175: 526: 38.79
+	Hs
		433721 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		LYN_HUMAN (9-508): 9.12e-173: 519: 36.15
+	Hs
		782781 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		CSK_HUMAN (61-500): 1.81e-155: 472: 37.72