HitPredict

Interactor 1: EFS (O43281)
Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3)
Gene: EFS

Interactor 2: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.931

Property	Details
Experiments	25416956, 32296183, 12471123, 31515488, unassigned1304
Identification Methods	two hybrid, pull down, enzymatic study, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005886 - plasma membrane GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 561 Hs			1 537
+	Hs
		199500 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		SRC_HUMAN (1-537): 0: 598: 68.21
+	Hs
		199498 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		YES_HUMAN (1-537): 0: 591: 71.61
+	Mm
		403448 EFS_MOUSE (1-561): 2.45e-61: 213: 79.50		SRC_MOUSE (1-537): 0: 599: 68.33
+	Hs
		412193 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		FYN_HUMAN (1-537): 0: 643: 100.00
+	Hs
		199508 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		BLK_HUMAN (28-532): 2.42e-179: 515: 56.72
+	Hs
		412152 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		FYN_HUMAN (1-537): 0: 643: 100.00
+	Mm
		639451 EFS_MOUSE (1-561): 2.45e-61: 213: 79.50		LYN_MOUSE (1-535): 0: 535: 53.92
+	Hs
		199495 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		ABL1_HUMAN (42-537): 7.36e-167: 504: 39.56
+	Hs
		522936 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		SRC_HUMAN (1-537): 0: 598: 68.21
+	Hs
		64077 L37A2_HUMAN (68-420): 4.98e-23: 106: 17.71		SRC_HUMAN (1-537): 0: 598: 68.21
+	Hs
		433331 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		YES_HUMAN (1-537): 0: 591: 71.61
+	Hs
		411721 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		LCK_HUMAN (40-535): 0: 551: 57.60
+	Hs
		297808 K0754_HUMAN (34-464): 4e-33: 137: 13.71		LYN_HUMAN (1-535): 0: 535: 54.48
+	Hs
		411790 MINK1_HUMAN (48-378): 5.94e-26: 115: 14.67		LCK_HUMAN (40-535): 0: 551: 57.60
+	Hs
		433761 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		LYN_HUMAN (1-535): 0: 535: 54.48
+	Hs
		442817 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		HCK_HUMAN (1-535): 0: 548: 56.64
+	Hs
		433891 MINK1_HUMAN (48-378): 5.94e-26: 115: 14.67		LYN_HUMAN (1-535): 0: 535: 54.48
+	Hs
		433721 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		LYN_HUMAN (1-535): 0: 535: 54.48
+	Hs
		337474 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		ABL1_HUMAN (42-537): 7.36e-167: 504: 39.56
+	Hs
		433853 MICA3_HUMAN (61-424): 2.25e-21: 100: 16.45		LYN_HUMAN (1-535): 0: 535: 54.48