HitPredict

Interactor 1: EFS (O43281)
Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3)
Gene: EFS

Interactor 2: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 561 Hs			1 724
+	Hs
		655334 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		655289 BCAR1_HUMAN (7-431): 2.78e-12: 71.7: 21.40		P85A_HUMAN (1-724): 0: 596: 100.00
+	Rn
		1144371 BCAR1_RAT (6-431): 4.77e-12: 70.9: 20.23		P85A_RAT (1-724): 0: 580: 94.20
+	Hs
		1054785 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		P55G_HUMAN (271-723): 1.4e-104: 329: 72.31
+	Hs
		992597 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		P55G_HUMAN (271-723): 1.4e-104: 329: 72.31
+	Hs
		199498 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		YES_HUMAN (568-724): 2.15e-31: 131: 20.61
+	Mm
		222876 ACK1_MOUSE (11-484): 7.98e-29: 124: 15.31		SRGP2_MOUSE (118-668): 2.74e-57: 212: 13.96
+	Mm
		222853 ACK1_MOUSE (11-484): 7.98e-29: 124: 15.31		RHG21_MOUSE (78-531): 4.18e-54: 204: 14.35
+	Mm
		222851 ACK1_MOUSE (11-484): 7.98e-29: 124: 15.31		RHG23_MOUSE (40-369): 2.01e-52: 199: 17.06
+	Hs
		253384 SH3R3_HUMAN (12-390): 3.66e-21: 99.8: 15.01		SRGP2_HUMAN (118-668): 3.41e-54: 203: 13.78
+	Hs
		1186087 MICA3_HUMAN (61-424): 2.25e-21: 100: 16.45		RGAP1_HUMAN (14-393): 1.43e-54: 200: 15.46
+	Hs
		64676 BCAR1_HUMAN (7-431): 2.78e-12: 71.7: 21.40		RHG32_HUMAN (14-613): 1.13e-61: 227: 13.99
+	Hs
		882397 BCAR1_HUMAN (7-431): 2.78e-12: 71.7: 21.40		SRGP1_HUMAN (86-631): 1.15e-53: 202: 11.88
+	Hs
		433331 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		YES_HUMAN (568-724): 2.15e-31: 131: 20.61
+	Hs
		433301 BCAR1_HUMAN (7-431): 2.78e-12: 71.7: 21.40		YES_HUMAN (568-724): 2.15e-31: 131: 20.61
+	Mm
		763397 BCAR1_MOUSE (7-431): 8.12e-11: 67: 19.17		FYN_MOUSE (573-724): 9.83e-33: 135: 22.50