HitPredict

Interactor 1: EFS (O43281)
Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3)
Gene: EFS

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	8647432, 17474147
Identification Methods	far western blotting, peptide array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH3_2~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016477 - cell migration GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 561 Hs			1 304
+	Mm
		192348 CASL_MOUSE (5-349): 2e-33: 137: 23.68		CRK_MOUSE (1-304): 5.53e-68: 215: 99.67
+	Hs
		199502 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		802600 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		199510 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		802577 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		802843 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		802742 CASS4_HUMAN (379-557): 1.65e-20: 97.9: 19.89		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		199489 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		199501 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		802828 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		924703 MINK1_HUMAN (48-378): 5.94e-26: 115: 14.67		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		924513 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		557691 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Mm
		222878 ACK1_MOUSE (11-484): 7.98e-29: 124: 15.31		NCK1_MOUSE (2-100): 1.35e-10: 63.3: 18.00
+	Hs
		209112 MINK1_HUMAN (48-378): 5.94e-26: 115: 14.67		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		557740 MINK1_HUMAN (48-378): 5.94e-26: 115: 14.67		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		209039 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		557670 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		1186102 MICA3_HUMAN (61-424): 2.25e-21: 100: 16.45		CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12
+	Hs
		203208 SYNJ1_HUMAN (95-472): 7.88e-19: 92.8: 13.96		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00