HitPredict

Interactor 1: EFS (O43281)
Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3)
Gene: EFS

Interactor 2: PTN12 (Q05209)
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Gene: PTPN12

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	9748319
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005925 - focal adhesion GO:0017124 - SH3 domain binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 561 Hs			1 780
+	Hs
		983485 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		PTN12_HUMAN (1-780): 0: 586: 100.00
+	Hs
		983476 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		PTN12_HUMAN (1-780): 0: 586: 100.00
+	Hs
		983518 CASS4_HUMAN (379-557): 1.65e-20: 97.9: 19.89		PTN12_HUMAN (1-780): 0: 586: 100.00
+	Hs
		882255 BCAR1_HUMAN (7-431): 2.78e-12: 71.7: 21.40		PTN12_HUMAN (1-780): 0: 586: 100.00
+	Mm
		728829 BCAR1_MOUSE (7-431): 8.12e-11: 67: 19.17		PTN12_MOUSE (1-780): 0: 560: 83.10
+	Hs
		441194 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30
+	Hs
		985955 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Hs
		573636 BCAR1_HUMAN (7-431): 2.78e-12: 71.7: 21.40		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Hs
		882258 BCAR1_HUMAN (7-431): 2.78e-12: 71.7: 21.40		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Rn
		783508 BCAR1_RAT (6-431): 4.77e-12: 70.9: 20.23		PTN11_RAT (7-351): 1.11e-123: 385: 31.48
+	Hs
		1069947 MINK1_HUMAN (48-378): 5.94e-26: 115: 14.67		PTPRK_HUMAN (17-297): 1.82e-59: 221: 26.64
+	Hs
		992570 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		PTPRJ_HUMAN (49-297): 6.23e-46: 179: 39.13