HitPredict

Interactor 1: M3K13 (O43283)
Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK)
Gene: MAP3K13

Interactor 2: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0019899 - enzyme binding GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 966 Hs			1 465
+	Hs
		226582 MARK3_HUMAN (112-852): 1.93e-124: 397: 13.68		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		227863 MARK2_HUMAN (113-852): 1.18e-123: 396: 16.29		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		226637 AKT1_HUMAN (109-491): 2.04e-127: 395: 20.40		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		226455 KPCA_HUMAN (25-493): 1.25e-123: 392: 20.08		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		226638 AKT2_HUMAN (131-492): 1e-125: 391: 20.00		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Mm
		337640 ABL1_MOUSE (156-939): 2.07e-121: 399: 20.42		PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66
+	Hs
		227317 STK4_HUMAN (146-548): 2.01e-121: 380: 22.04		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		682055 AKT1_HUMAN (109-491): 2.04e-127: 395: 20.40		RNF14_HUMAN (161-464): 6.69e-69: 229: 21.56
+	Hs
		566475 KPCA_HUMAN (25-493): 1.25e-123: 392: 20.08		HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36
+	Hs
		474935 AKT1_HUMAN (109-491): 2.04e-127: 395: 20.40		UBB_HUMAN (1-234): 1.14e-59: 197: 17.92
+	Hs
		474936 AKT2_HUMAN (131-492): 1e-125: 391: 20.00		UBB_HUMAN (1-234): 1.14e-59: 197: 17.92
+	Zm
		31754 A0A1D6QQC6_MAIZE (29-407): 1.15e-105: 350: 29.80		A0A1D6KKQ6_MAIZE (220-456): 3.55e-70: 236: 20.08
+	Xl
		1186347 M3K10_XENLA (162-939): 1.8e-122: 399: 24.23		Q7SY79_XENLA (1-149): 2.25e-49: 179: 19.33
+	Hs
		475012 STK4_HUMAN (146-548): 2.01e-121: 380: 22.04		UBB_HUMAN (1-234): 1.14e-59: 197: 17.92
+	At
		1091641 KIN10_ARATH (167-522): 2.91e-128: 399: 21.41		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		475390 AKT1_HUMAN (109-491): 2.04e-127: 395: 20.40		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		475314 KPCA_HUMAN (25-493): 1.25e-123: 392: 20.08		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		475345 KS6B1_HUMAN (109-594): 1.03e-123: 388: 16.67		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	At
		955189 KIN11_ARATH (167-498): 1.98e-123: 386: 21.04		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		1346317 M3K20_HUMAN (162-484): 1.29e-108: 356: 35.65		RN19A_HUMAN (236-452): 6.6e-31: 128: 21.62