HitPredict

Interactor 1: SPIT2 (O43291)
Kunitz-type protease inhibitor 2 (Hepatocyte growth factor activator inhibitor type 2) (HAI-2) (Placental bikunin)
Gene: SPINT2

Interactor 2: A4 (P05067)
Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
Gene: APP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21832049
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Kunitz_BPTI~Kunitz_BPTI
Common GO terms	GO:0004867 - serine-type endopeptidase inhibitor activity GO:0005576 - extracellular region GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 252 Hs			1 770
+	Mm
		517574 A4_MOUSE (136-184): 1.22e-20: 92.5: 55.10		A4_MOUSE (1-770): 0: 1016: 96.62
+	Hs
		394591 APLP2_HUMAN (31-132): 9.41e-25: 104: 22.55		A4_HUMAN (19-770): 0: 999: 100.00
+	Hs
		393906 A4_HUMAN (136-184): 1.61e-20: 92.1: 55.10		A4_HUMAN (19-770): 0: 999: 100.00
+	Hs
		987497 APLP2_HUMAN (31-132): 9.41e-25: 104: 22.55		APLP2_HUMAN (3-769): 0: 858: 49.17
+	Mm
		517626 A4_MOUSE (136-184): 1.22e-20: 92.5: 55.10		APLP2_MOUSE (3-769): 0: 753: 44.32
+	Hs
		849928 APLP2_HUMAN (31-132): 9.41e-25: 104: 22.55		APLP1_HUMAN (6-194): 9.65e-70: 243: 45.79
+	Hs
		394370 A4_HUMAN (136-184): 1.61e-20: 92.1: 55.10		APLP1_HUMAN (6-194): 9.65e-70: 243: 45.79
+	Mm
		517625 A4_MOUSE (136-184): 1.22e-20: 92.5: 55.10		APLP1_MOUSE (5-193): 1.54e-68: 240: 44.74
+	Mm
		1144386 CO7A1_MOUSE (36-88): 1.28e-20: 92.9: 40.00		CO7A1_MOUSE (234-343): 3.63e-26: 118: 33.93
+	Mm
		93247 E9PWQ3_MOUSE (33-90): 1.55e-22: 98.3: 37.93		E9PWQ3_MOUSE (250-345): 1.6e-21: 103: 27.08
+	Hs
		393997 A4_HUMAN (136-184): 1.61e-20: 92.1: 55.10		TFPI1_HUMAN (251-411): 3.44e-25: 108: 17.01
+	Hs
		363399 AMBP_HUMAN (36-103): 3.55e-16: 78.7: 33.82		AMBP_HUMAN (258-350): 2.03e-18: 89.6: 32.26