HitPredict

Interactor 1: SPIT2 (O43291)
Kunitz-type protease inhibitor 2 (Hepatocyte growth factor activator inhibitor type 2) (HAI-2) (Placental bikunin)
Gene: SPINT2

Interactor 2: LRP10 (Q7Z4F1)
Low-density lipoprotein receptor-related protein 10 (LRP-10)
Gene: LRP10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 252 Hs			1 713
+	Hs
		199980 SPIT2_HUMAN (1-252): 4.61e-93: 275: 100.00		LRP12_HUMAN (1-698): 2.08e-113: 363: 31.77
+	Hs
		199981 SPIT2_HUMAN (1-252): 4.61e-93: 275: 100.00		ST14_HUMAN (6-300): 5.21e-37: 150: 14.65
+	Hs
		987565 APLP2_HUMAN (31-132): 9.41e-25: 104: 22.55		ST14_HUMAN (6-300): 5.21e-37: 150: 14.65
+	Hs
		396137 A4_HUMAN (136-184): 1.61e-20: 92.1: 55.10		ST14_HUMAN (6-300): 5.21e-37: 150: 14.65
+	Hs
		199487 SPIT1_HUMAN (38-95): 1.03e-14: 75.2: 37.93		ST14_HUMAN (6-300): 5.21e-37: 150: 14.65
+	Dm
		78469 Q4V621_DROME (129-185): 1.9e-17: 76.3: 46.55		B5X533_DROME (49-354): 1.38e-32: 137: 10.90
+	Oc
		101994 G1SZM2_RABIT (42-91): 5.6e-21: 93.7: 48.00		SORL_RABIT (85-296): 2.55e-26: 118: 13.49
+	Hs
		395362 A4_HUMAN (136-184): 1.61e-20: 92.1: 55.10		SORL_HUMAN (305-535): 1.96e-22: 105: 14.48
+	Mm
		291358 A4_MOUSE (136-184): 1.22e-20: 92.5: 55.10		SORL_MOUSE (306-535): 5.56e-22: 104: 14.53
+	Hs
		394121 A4_HUMAN (136-184): 1.61e-20: 92.1: 55.10		TENX_HUMAN (263-612): 1.45e-21: 102: 12.63
+	Dm
		78519 Q9VQT8_DROME (47-90): 5.44e-09: 53.6: 43.18		B5X533_DROME (49-354): 1.38e-32: 137: 10.90
+	Hs
		817020 TFPI2_HUMAN (128-192): 3.99e-16: 76.7: 41.54		SORL_HUMAN (305-535): 1.96e-22: 105: 14.48
+	Hs
		987510 APLP2_HUMAN (31-132): 9.41e-25: 104: 22.55		LRP8_HUMAN (89-230): 6.24e-11: 68: 19.46
+	Hs
		216997 A4_HUMAN (136-184): 1.61e-20: 92.1: 55.10		TLL1_HUMAN (25-143): 2.96e-13: 75.7: 15.50
+	Hs
		394598 A4_HUMAN (136-184): 1.61e-20: 92.1: 55.10		LRP1_HUMAN (176-434): 6.1e-11: 68.4: 10.23
+	Hs
		394702 A4_HUMAN (136-184): 1.61e-20: 92.1: 55.10		LRP8_HUMAN (89-230): 6.24e-11: 68: 19.46
+	Hs
		394536 A4_HUMAN (136-184): 1.61e-20: 92.1: 55.10		LRP2_HUMAN (344-521): 1.01e-09: 64.6: 20.33
+	Hs
		395938 A4_HUMAN (136-184): 1.61e-20: 92.1: 55.10		LRP1B_HUMAN (299-490): 9.54e-09: 61.1: 14.57