HitPredict

Interactor 1: DAPK3 (O43293)
Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (Zipper-interacting protein kinase) (ZIP-kinase)
Gene: DAPK3

Interactor 2: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35509820
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010506 - regulation of autophagy GO:0042981 - regulation of apoptotic process
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 465
+	Hs
		227381 KCC2D_HUMAN (2-350): 4.78e-128: 381: 31.77		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		229082 KCC2A_HUMAN (1-361): 3.45e-125: 373: 31.25		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		227554 MYLK_HUMAN (6-308): 2.38e-74: 256: 43.09		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		228658 MYLK2_HUMAN (1-308): 3.9e-66: 224: 40.06		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Sc
		419769 SNF1_YEAST (12-401): 1.4e-132: 398: 27.48		UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72
+	At
		1091642 CDPKB_ARATH (3-442): 3.88e-149: 435: 24.89		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		475511 DAPK1_HUMAN (1-279): 3.41e-134: 421: 81.36		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	At
		1091676 CDPK3_ARATH (1-445): 9.92e-144: 422: 28.19		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		1091633 CDPK5_ARATH (4-453): 1.34e-141: 418: 25.70		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		1092417 CDPKQ_ARATH (5-444): 1.57e-142: 418: 26.92		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		1091641 KIN10_ARATH (7-375): 3.4e-137: 405: 29.73		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		475723 KCC2D_HUMAN (2-350): 4.78e-128: 381: 31.77		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	At
		955189 KIN11_ARATH (7-304): 1.55e-125: 375: 33.11		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		1083218 KCC4_HUMAN (6-298): 8.21e-63: 212: 40.60		CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58