HitPredict

Interactor 1: TGFI1 (O43294)
Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5)
Gene: TGFB1I1

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	37219487
Identification Methods	unspecified method, phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 461 Hs			1 903
+	Mm
		1143674 TGFI1_MOUSE (1-461): 4.55e-98: 303: 91.32		ITCH_MOUSE (1-903): 0: 885: 91.16
+	Hs
		200184 TGFI1_HUMAN (1-461): 8.49e-99: 305: 100.00		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		200165 TGFI1_HUMAN (1-461): 8.49e-99: 305: 100.00		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		1327916 PDLI7_HUMAN (343-461): 4.25e-34: 134: 34.45		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		125735 PDLI7_HUMAN (343-461): 4.25e-34: 134: 34.45		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		808283 PDLI7_HUMAN (343-461): 4.25e-34: 134: 34.45		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		1336088 PDLI7_HUMAN (343-461): 4.25e-34: 134: 34.45		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Hs
		816282 LIMS1_HUMAN (212-340): 4.04e-24: 104: 24.69		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Hs
		1050798 FHL2_HUMAN (199-337): 2.52e-24: 103: 23.78		SMUF2_HUMAN (1-358): 2.56e-46: 180: 16.94