HitPredict

Interactor 1: SRGP3 (O43295)
SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP)
Gene: SRGAP3

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	32203420
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1099 Hs			1 192
+	Hs
		925395 SRGP1_HUMAN (1-1087): 0: 708: 67.83		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		900637 SRGP1_HUMAN (1-1087): 0: 708: 67.83		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		253337 SRGP2_HUMAN (1-1087): 0: 675: 57.36		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		253311 SRGP2_HUMAN (1-1087): 0: 675: 57.36		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		253333 SRGP2_HUMAN (1-1087): 0: 675: 57.36		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Mm
		892733 SRGP1_MOUSE (1-1087): 0: 677: 65.90		CDC42_MOUSE (1-192): 1.4e-78: 234: 70.31
+	Mm
		1265268 SRGP1_MOUSE (1-1087): 0: 677: 65.90		RHOA_MOUSE (5-192): 1.43e-77: 231: 57.98
+	Hs
		925192 RHG04_HUMAN (1-948): 2.35e-172: 532: 43.83		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		900540 RHG29_HUMAN (44-1085): 3.59e-108: 368: 15.42		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		245184 OPHN1_HUMAN (148-911): 3.02e-98: 331: 15.10		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		925688 GMIP_HUMAN (47-877): 1.46e-95: 328: 15.13		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Dm
		776930 RHGF_DROME (133-1098): 4.49e-96: 331: 13.77		RAC1_DROME (1-192): 8.65e-83: 245: 91.67
+	Hs
		245182 OPHN1_HUMAN (148-911): 3.02e-98: 331: 15.10		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		894533 GMIP_HUMAN (47-877): 1.46e-95: 328: 15.13		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		245183 OPHN1_HUMAN (148-911): 3.02e-98: 331: 15.10		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		63065 RHG42_HUMAN (148-969): 1.9e-92: 317: 13.35		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		900997 GMIP_HUMAN (47-877): 1.46e-95: 328: 15.13		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		49630 RHG10_HUMAN (149-893): 2.06e-95: 323: 14.98		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		49631 RHG10_HUMAN (149-893): 2.06e-95: 323: 14.98		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		63072 RHG42_HUMAN (148-969): 1.9e-92: 317: 13.35		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19