Interactor 1: M3K7 (O43318)
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Gene: MAP3K7

Interactor 2: M3K7 (O43318)
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Gene: MAP3K7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.982

The method score is based on:

Property Details
Experiments 12624112, 27497262, 31980649, 9556573, 34490261, 12482967, 9742107, 19232515, 20538596, 10702308, 21817100, 15590691, 14743216
Identification Methods enzymatic study, affinity chromatography technology, pull down, in-gel kinase assay, tandem affinity purification
Interaction Type direct interaction, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms GO:0000165 - MAPK cascade
GO:0000287 - magnesium ion binding
GO:0001223 - transcription coactivator binding
GO:0002223 - stimulatory C-type lectin receptor signaling pathway
GO:0002726 - positive regulation of T cell cytokine production
and 57 others

more...

Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 606
Hs

1 606
+ Mm
+ At
+ At
+ At
+ Hs
+ At
+ Mm
+ Rn
+ At
+ Rn
+ Gg
+ At
+ At
+ At
+ Dm
+ Hs
+ At
+ Hs

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Last updated: 15 Jul 2024