HitPredict

Interactor 1: M3K7 (O43318)
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Gene: MAP3K7

Interactor 2: XIAP (P98170)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.75 1.00 0.871

The method score is based on:

Property Details
Experiments 12048196, 19584092, 11865055
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains BIR~PK_Tyr_Ser-Thr
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0042742 - defense response to bacterium
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
and 1 others

more...
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 606
Hs

1 497
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024