HitPredict

Interactor 1: M3K7 (O43318)
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Gene: MAP3K7

Interactor 2: FKBP4 (Q02790)
Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]
Gene: FKBP4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~PK_Tyr_Ser-Thr
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 606 Hs			1 459
+	Hs
		201328 M3K7_HUMAN (1-606): 0: 574: 100.00		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		983602 FAK1_HUMAN (30-603): 3.48e-121: 385: 21.04		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		972616 RIPK3_HUMAN (31-498): 1.9e-103: 324: 25.29		FKBP4_HUMAN (1-459): 1.71e-150: 437: 100.00
+	Hs
		1035071 RIPK3_HUMAN (31-498): 1.9e-103: 324: 25.29		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		684651 FAK1_HUMAN (30-603): 3.48e-121: 385: 21.04		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51
+	Hs
		685142 RIPK3_HUMAN (31-498): 1.9e-103: 324: 25.29		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51
+	Hs
		118747 TNI3K_HUMAN (35-281): 1.8e-39: 156: 37.55		AIP_HUMAN (146-416): 1.8e-50: 176: 20.12