HitPredict

Interactor 1: M3K7 (O43318)
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Gene: MAP3K7

Interactor 2: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	33961781, 32707033, 14743216
Identification Methods	affinity chromatography technology, tandem affinity purification, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 606 Hs			1 457
+	Hs
		201309 M3K7_HUMAN (1-606): 0: 574: 100.00		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		983602 FAK1_HUMAN (30-603): 3.48e-121: 385: 21.04		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		1035071 RIPK3_HUMAN (31-498): 1.9e-103: 324: 25.29		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		972616 RIPK3_HUMAN (31-498): 1.9e-103: 324: 25.29		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		684651 FAK1_HUMAN (30-603): 3.48e-121: 385: 21.04		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		685142 RIPK3_HUMAN (31-498): 1.9e-103: 324: 25.29		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		118747 TNI3K_HUMAN (35-281): 1.8e-39: 156: 37.55		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72