HitPredict

Interactor 1: M3K7 (O43318)
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Gene: MAP3K7

Interactor 2: TAB3 (Q8N5C8)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3)
Gene: TAB3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	0.60	0.767

Property	Details
Experiments	27497262, 14670075, 14633987, 27009840, 30348973, 31127032, 32229191, 33717111, 34535633, 21903422, 18021073, 22081109, 17384642, 24912525, 28507161, 32410369, 35271311, 32707033, 36593296, 19232515 and 2 others more... 17158449, 14743216
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0010008 - endosome membrane GO:0042742 - defense response to bacterium GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 606 Hs			1 712
+	Mm
		1123042 M3K7_MOUSE (1-606): 0: 545: 94.88		TAB3_MOUSE (1-712): 2.53e-96: 315: 94.69
+	Hs
		201449 M3K7_HUMAN (1-606): 0: 574: 100.00		TAB2_HUMAN (1-711): 6.6e-48: 182: 30.53
+	Rn
		473815 M3K7_RAT (1-606): 0: 573: 99.01		TAB2_RAT (1-711): 3.62e-45: 174: 28.09
+	Mm
		1143268 M3K7_MOUSE (1-606): 0: 545: 94.88		TAB2_MOUSE (1-711): 4.55e-45: 173: 28.09