HitPredict

Interactor 1: M3K7 (O43318)
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Gene: MAP3K7

Interactor 2: CHIP (Q9UNE7)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: STUB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34535633, 23322406
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000165 - MAPK cascade GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding and 1 others more... GO:0071456 - cellular response to hypoxia
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 606 Hs			1 303
+	Hs
		201277 M3K7_HUMAN (1-606): 0: 574: 100.00		PPP5_HUMAN (1-259): 1.3e-35: 135: 20.91
+	Mm
		1141210 M3K7_MOUSE (1-606): 0: 545: 94.88		PPP5_MOUSE (1-259): 7.23e-36: 136: 20.91
+	Hs
		983691 FAK1_HUMAN (30-603): 3.48e-121: 385: 21.04		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Mm
		710144 FAK1_MOUSE (30-603): 3.08e-120: 383: 21.49		WDTC1_MOUSE (21-272): 7.36e-30: 120: 19.22
+	Hs
		945783 M3K9_HUMAN (3-285): 4.42e-39: 155: 36.55		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Hs
		1083523 M3K11_HUMAN (29-287): 5.32e-37: 149: 35.27		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Mm
		1194935 M3K20_MOUSE (27-287): 1.65e-39: 156: 36.16		WDTC1_MOUSE (21-272): 7.36e-30: 120: 19.22