HitPredict

Interactor 1: M3K7 (O43318)
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Gene: MAP3K7

Interactor 2: JIP1 (Q9UQF2)
C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1)
Gene: MAPK8IP1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	18286207, 17709393, 16840345
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol GO:0005886 - plasma membrane and 1 others more... GO:0007254 - JNK cascade
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 606 Hs			1 711
+	Mm
		1265829 Q923A8_MOUSE (1-606): 0: 573: 99.34		JIP1_MOUSE (1-711): 0: 995: 93.40
+	Mm
		1143278 M3K7_MOUSE (1-606): 0: 545: 94.88		JIP1_MOUSE (1-711): 0: 995: 93.40
+	Hs
		972470 M3K10_HUMAN (29-282): 2.43e-45: 174: 38.89		JIP1_HUMAN (1-711): 0: 955: 100.00
+	Hs
		1083525 M3K11_HUMAN (29-287): 5.32e-37: 149: 35.27		JIP1_HUMAN (1-711): 0: 955: 100.00
+	Mm
		1206693 FAK2_MOUSE (31-603): 4.29e-116: 371: 19.06		ANS1B_MOUSE (424-700): 3.02e-69: 248: 19.30
+	Hs
		666080 FAK1_HUMAN (30-603): 3.48e-121: 385: 21.04		SHC1_HUMAN (417-700): 6.37e-34: 139: 17.04
+	Hs
		666110 FAK2_HUMAN (31-603): 1.5e-116: 372: 18.58		SHC1_HUMAN (417-700): 6.37e-34: 139: 17.04
+	Hs
		253546 EPHA5_HUMAN (16-325): 4.76e-100: 328: 28.27		CAPON_HUMAN (545-707): 1.47e-38: 151: 20.69
+	Hs
		833552 EPHA5_HUMAN (16-325): 4.76e-100: 328: 28.27		NUMB_HUMAN (548-704): 2.36e-36: 147: 18.41
+	Hs
		665145 EPHA2_HUMAN (16-358): 2.84e-101: 331: 26.67		SHC1_HUMAN (417-700): 6.37e-34: 139: 17.04
+	Hs
		666048 EPHA5_HUMAN (16-325): 4.76e-100: 328: 28.27		SHC1_HUMAN (417-700): 6.37e-34: 139: 17.04
+	Hs
		972457 M3K10_HUMAN (29-282): 2.43e-45: 174: 38.89		JIP2_HUMAN (25-273): 1.95e-67: 239: 31.92
+	Hs
		1032911 M3K11_HUMAN (29-287): 5.32e-37: 149: 35.27		JIP2_HUMAN (25-273): 1.95e-67: 239: 31.92