HitPredict

Interactor 1: M3K7 (O43318)
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Gene: MAP3K7

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 606 Hs			1 456
+	Hs
		201471 M3K7_HUMAN (1-606): 0: 574: 100.00		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Dm
		1359057 M3K7_DROME (31-593): 6.48e-121: 374: 33.06		RUVB1_DROME (1-455): 0: 660: 79.56
+	Hs
		1377048 RIPK3_HUMAN (31-498): 1.9e-103: 324: 25.29		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Dm
		1358862 M3K7_DROME (31-593): 6.48e-121: 374: 33.06		RUVB2_DROME (5-455): 0: 640: 45.25
+	Hs
		1376988 RIPK3_HUMAN (31-498): 1.9e-103: 324: 25.29		RUVB2_HUMAN (2-455): 0: 651: 42.76